RNF2

Gene Symbol RNF2
Entrez Gene 6045
Alt Symbol BAP-1, BAP1, DING, HIPI3, RING1B, RING2
Species Human
Gene Type protein-coding
Description ring finger protein 2
Other Description E3 ubiquitin-protein ligase RING2|HIP2-interacting protein 3|RING finger protein 1B|RING finger protein BAP-1|huntingtin-interacting protein 2-interacting protein 3|protein DinG
Swissprots B2RBS7 Q5TEN2 Q5TEN1 Q99496 B3KRH1
Accessions EAW91187 EAW91188 Q99496 AF075026 AF141327 AAD29717 AI242656 AK091574 BAG52383 AK314793 BAG37324 BC012583 AAH12583 BF183837 BX338357 DQ892932 ABM83858 DQ896181 ABM87180 Y10571 CAA71596 XM_005245413 XP_005245470 XM_011509851 XP_011508153 XM_011509852 XP_011508154 NM_007212 NP_009143
Function E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), thereby playing a central role in histone code and gene regulation. H2AK119Ub gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. May be involved in the initiation of both imprinted and random X inactivation. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. E3 ubiquitin-protein ligase activity is enhanced by BMI1/PCGF4. Acts as the main E3 ubiquitin ligase on histone H2A of the PRC1 complex, while RING1 may rather act as a modulator of RNF2/RING2 activity. In resting B- and T-lymphocytes, interaction with AURKB le
Subcellular Location Nucleus {ECO:0000269|PubMed:21282530}. Chromosome {ECO:0000250}. Note=Enriched on inactive X chromosome (Xi) in female trophoblast stem (TS) cells as well as differentiating embryonic stem (ES) cells. The enrichment on Xi is transient during TS and ES cell differentiation. The association with Xi is mitotically stable in non-differentiated TS cells (By similarity). {ECO:0000250}.

RING1B (D22F2) XP ® Rabbit mAb - 5694 from Cell Signaling Technology

Prices $109.00, $277.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D22F2
Western blot analysis of extracts from various cell lines using RING1B (D22F2) XP ® Rabbit mAb.

RING1B (N-32) - sc-101109 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
RING1B (N-32): sc-101109. Western blot analysis of RING1B expression in NIH/3T3 whole cell lysate.

RING1B (C-14) - sc-66257 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

RING1B (P-15) - sc-66261 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

RING1B (S-20) - sc-66263 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-RING2 / RING1B / RNF2 antibody - ab194666 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Anti-RING2 / RING1B / RNF2 antibody (ab194666) at 5 µg/ml + Human stomach lysate at 50 µgdeveloped using the ECL technique

Anti-RING2 / RING1B / RNF2 antibody - ab187509 from Abcam

Prices $384.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human breast cancer tissue labelling RING2 / RING1B / RNF2 with ab187509 at 1/200. Magnification: 400x.

Anti-RING2 / RING1B / RNF2 antibody - ab14751 from Abcam

Prices $378.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Anti-RING2 / RING1B / RNF2 antibody (ab14751) at 0.5 µg/ml + Cell lysate prepared from human K562 cells at 35 µgdeveloped using the ECL technique

Anti-RING2 / RING1B / RNF2 antibody - ab106305 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-RING2 / RING1B / RNF2 antibody (ab106305) at 1 µg/mlLane 1 : HeLa (Human epithelial carcinoma cell line) Whole Cell LysateLane 2 : Jurkat (Human T cell lymphoblast-like cell line) Whole Cell LysateLane 3 : HEK293 (Human embryonic kidney cell line) Whole Cell LysateLane 4 : K562 (Human erythromyeloblastoid leukemia cell line) Whole Cell LysateLane 5 : U937 (Human leukemic monocyte lymphoma cell line) Whole Cell LysateLane 6 : NIH 3T3 (Mouse embryonic fibroblast cell line) Whole Cell LysateLane 7 : CHO-K1 cell lysate Whole Cell LysateLysates/proteins at 10 µg per lane.SecondaryGoat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-RING2 / RING1B / RNF2 antibody [EPR12245] - ab181140 from Abcam

Prices $384.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR12245
All lanes : Anti-RING2 / RING1B / RNF2 antibody [EPR12245] (ab181140) at 1/10000 dilutionLane 1 : HeLa cell lysateLane 2 : 293 cell lysateLane 3 : Jurkat cell lysateLane 4 : HepG2 cell lysateLysates/proteins at 20 µg per lane.SecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugate at 1/1000 dilution

Anti-RING2 / RING1B / RNF2 antibody [EPR12246] - C-terminal - ab174282 from Abcam

Prices $378.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR12246
Immunofluorescent analysis of HeLa cells labeling RING2 / RING1B / RNF2 with ab174282 at 1/100.

Anti-RING2 / RING1B / RNF2 antibody - ChIP Grade - ab3832 from Abcam

Prices $394.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-RNF2 / RING2 / RING1B Antibody (aa181-230) - LS-C29850 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Daudi Cell Lysate

Anti-RNF2 / RING2 / RING1B Antibody (clone 3-3) - LS-C179401 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3-3

Anti-RNF2 / RING2 / RING1B Antibody (C-Terminus) - LS-C55401 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Antibody staining (1 ug/ml) of Human Bone Marrow lysate (RIPA buffer, 35 ug total protein per lane). Primary incubated for 1 hour. Detected by Western blot of chemiluminescence.

Anti-RNF2 / RING2 / RING1B Antibody (aa286-336) - LS-C289585 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-RNF2 / RING2 / RING1B Antibody (aa228-277) - LS-C30670 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
RNF2 antibody LS-C30670 was used in IHC to stain formalin-fixed, paraffin-embedded human kidney.

Anti-RING1B / BAP1 / RNF2 Antibody (aa192-291, Azide-free) - LS-C330639 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal

Anti-RNF2 / RING2 / RING1B Antibody - LS-C342242 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-RNF2 / RING2 / RING1B Antibody (aa156-205) - LS-C206158 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
RING1B / BAP1 / RNF2 antibody Western Blot of MDA-MB-435s. Antibody dilution: 1 ug/ml.

Anti-RNF2 / RING2 / RING1B Antibody (aa189-201) IHC-plus™ - LS-B417 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
Anti-RNF2 antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B417 concentration 2.5 ug/ml.

Anti-RNF2 / RING2 / RING1B Antibody - LS-C334144 from LifeSpan Bioscience

Prices $255.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry of paraffin-embedded human breast cancer using RNF2 antibody at dilution of 1:200 (400x lens).

Anti-RNF2 / RING2 / RING1B Antibody (clone 3G6) - LS-C139336 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3G6
RNF2 monoclonal antibody (M03), clone 3G6. Western blot of RNF2 expression in Raw 264.7.

Anti-RNF2 / RING2 / RING1B Antibody (clone 4A9) - LS-C139193 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 4A9
RNF2 monoclonal antibody (M06), clone 4A9. Western blot of RNF2 expression in Raw 264.7.

Anti-RNF2 / RING2 / RING1B Antibody (clone 2B4) - LS-C139289 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2B4
RNF2 monoclonal antibody (M14), clone 2B4. Western blot of RNF2 expression in Raw 264.7.
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