| Gene Symbol |
PHF21A
|
| Entrez Gene |
51317
|
| Alt Symbol |
BHC80, BM-006
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
PHD finger protein 21A
|
| Other Description |
BHC80a|BRAF35-HDAC complex protein BHC80|BRAF35/HDAC2 complex (80 kDa)
|
| Swissprots |
Q9C0G7 Q9H8V9 D3DQP5 Q6AWA2 Q9NZE9 Q9HAK6 Q96BD5
|
| Accessions |
EAW68012 EAW68013 EAW68014 EAW68015 EAW68016 EAW68017 EAW68018 Q96BD5 AB051483 BAB21787 AF208848 AAF64262 AK021530 BAB13839 AK023258 BAB14492 AL359593 AL359608 AY090777 AAM09095 BC015714 AAH15714 BX648236 CAH10542 CB266669 EU446805 ABZ92334 XM_005252962 XP_005253019 XM_005252965 XP_005253022 XM_006718248 XP_006718311 XM_011520157 XP_011518459 XM_011520158 XP_011518460 XM_011520159 XP_011518461 XM_011520160 XP_011518462 XM_011520161 XP_011518463 XM_011520162 XP_011518464 XM_011520163 XP_011518465 XM_011520164 XP_011518466 XM_011520165 XP_011518467 XM_011520166 XP_011518468 XM_011520167 XP_011518469 XM_011520168 XP_011518470 XM_011520169 XP_011518471 XM_011520170 XP_011518472 XM_011520171 XP_011518473 XM_011520172 XP_011518474 XM_011520173 XP_011518475 XM_011520174 XP_011518476 XM_011520175 XP_011518477 XM_011520176 XP_011518478 XM_011520177 XP_011518479 XM_011520178 XP_011518480 XM_011520179 XP_011518481 XM_011520180 XP_011518482 XM_011520181 XP_011518483 XM_011520182 XP_011518484 XR_930874 NM_001101802 NP_001095272 NM_016621 NP_057705
|
| Function |
Component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it may act as a scaffold. Inhibits KDM1A-mediated demethylation of 'Lys-4' of histone H3 in vitro, suggesting a role in demethylation regulation. {ECO:0000269|PubMed:16140033}.
|
| Subcellular Location |
Nucleus {ECO:0000250}.
|
| Tissue Specificity |
Highly expressed in brain. Expressed at much lower level in other tissues. {ECO:0000269|PubMed:12032298}.
|