Gene Symbol | PHF21A |
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Entrez Gene | 51317 |
Alt Symbol | BHC80, BM-006 |
Species | Human |
Gene Type | protein-coding |
Description | PHD finger protein 21A |
Other Description | BHC80a|BRAF35-HDAC complex protein BHC80|BRAF35/HDAC2 complex (80 kDa) |
Swissprots | Q9C0G7 Q9H8V9 D3DQP5 Q6AWA2 Q9NZE9 Q9HAK6 Q96BD5 |
Accessions | EAW68012 EAW68013 EAW68014 EAW68015 EAW68016 EAW68017 EAW68018 Q96BD5 AB051483 BAB21787 AF208848 AAF64262 AK021530 BAB13839 AK023258 BAB14492 AL359593 AL359608 AY090777 AAM09095 BC015714 AAH15714 BX648236 CAH10542 CB266669 EU446805 ABZ92334 XM_005252962 XP_005253019 XM_005252965 XP_005253022 XM_006718248 XP_006718311 XM_011520157 XP_011518459 XM_011520158 XP_011518460 XM_011520159 XP_011518461 XM_011520160 XP_011518462 XM_011520161 XP_011518463 XM_011520162 XP_011518464 XM_011520163 XP_011518465 XM_011520164 XP_011518466 XM_011520165 XP_011518467 XM_011520166 XP_011518468 XM_011520167 XP_011518469 XM_011520168 XP_011518470 XM_011520169 XP_011518471 XM_011520170 XP_011518472 XM_011520171 XP_011518473 XM_011520172 XP_011518474 XM_011520173 XP_011518475 XM_011520174 XP_011518476 XM_011520175 XP_011518477 XM_011520176 XP_011518478 XM_011520177 XP_011518479 XM_011520178 XP_011518480 XM_011520179 XP_011518481 XM_011520180 XP_011518482 XM_011520181 XP_011518483 XM_011520182 XP_011518484 XR_930874 NM_001101802 NP_001095272 NM_016621 NP_057705 |
Function | Component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it may act as a scaffold. Inhibits KDM1A-mediated demethylation of 'Lys-4' of histone H3 in vitro, suggesting a role in demethylation regulation. {ECO:0000269|PubMed:16140033}. |
Subcellular Location | Nucleus {ECO:0000250}. |
Tissue Specificity | Highly expressed in brain. Expressed at much lower level in other tissues. {ECO:0000269|PubMed:12032298}. |
Human BHC80 / PHF21A peptide - ab41630 from Abcam
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Human BHC80 / PHF21A protein fragment - ab162507 from Abcam
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PHF21A / BHC80 Antibody Blocking Peptide - LS-E4234 from LifeSpan Bioscience
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PHF21A / BHC80 Antibody Blocking Peptide - LS-E12268 from LifeSpan Bioscience
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PHF21A / BHC80 Antibody Blocking Peptide - LS-E14171 from LifeSpan Bioscience
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Recombinant Human PHF21A Protein - H00051317-Q01 from Novus Biologicals
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PHF21A-Antibody-Center-Blocking-Peptide - BP16505c from Abgent, a WuXi AppTec company
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PHF21A - H00051317-Q01-10 from Acris Antibodies
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PHF21A - H00051317-Q01-25 from Acris Antibodies
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PHF21A fusion protein - ag19296 from Proteintech Group
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PHF21A fusion protein - ag2771 from Proteintech Group
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Recombinant Human PHD finger protein 21A(PHF21A) - CSB-YP017911HU CSB-EP017911HU CSB-BP017911HU CSB-MP017911HU from Cusabio
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PHD finger protein 21A (PHF21A), Recombinant Protein - MBS1350251 from MyBioSource
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PHF21A Recombinant Protein Antigen - NBP1-92262PEP from Novus Biologicals
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PHF21A Peptide, Human - M34GP11697H from Creative Peptides
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