| Gene Symbol |
F2RL3
|
| Entrez Gene |
9002
|
| Alt Symbol |
PAR4
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
coagulation factor II (thrombin) receptor-like 3
|
| Other Description |
PAR-4|protease-activated receptor-4|proteinase-activated receptor 4|thrombin receptor-like 3
|
| Swissprots |
O76067 Q6DK42 Q96RI0
|
| Accessions |
AAK61908 EAW84566 Q96RI0 AF055917 AAC25699 AF080214 AAC28860 AY431102 AAR08487 BC074782 AAH74782 XM_005260139 XP_005260196 NM_003950 NP_003941
|
| Function |
Receptor for activated thrombin or trypsin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation. {ECO:0000269|PubMed:10079109}.
|
| Subcellular Location |
Cell membrane; Multi-pass membrane protein.
|
| Tissue Specificity |
Widely expressed, with highest levels in lung, pancreas, thyroid, testis and small intestine. Not expressed in brain, kidney, spinal cord and peripheral blood leukocytes. Also detected in platelets.
|
| Top Pathways |
Rap1 signaling pathway, Neuroactive ligand-receptor interaction
|