| Gene Symbol |
CHAF1B
|
| Entrez Gene |
8208
|
| Alt Symbol |
CAF-1, CAF-IP60, CAF1, CAF1A, CAF1P60, MPHOSPH7, MPP7
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
chromatin assembly factor 1, subunit B (p60)
|
| Other Description |
CAF-1 subunit B|CAF-I 60 kDa subunit|CAF-I p60|M-phase phosphoprotein 7|chromatin assembly factor 1 subunit B|chromatin assembly factor I p60 subunit|human chromatin assembly factor-I p60 subunit
|
| Swissprots |
Q13112 Q99548
|
| Accessions |
BAA89426 BAA95549 EAX09741 Q13112 AJ001856 AK092781 AK313152 BAG35970 AL711314 BC001143 BC021218 AAH21218 JF432525 ADZ15742 U20980 AAA76737 X98262 CAA66915 XM_011529753 XP_011528055 XM_011529754 XP_011528056 XM_011529755 XP_011528057 NM_005441 NP_005432
|
| Function |
Complex that is thought to mediate chromatin assembly in DNA replication and DNA repair. Assembles histone octamers onto replicating DNA in vitro. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer. {ECO:0000269|PubMed:9813080}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:9614144}. Cytoplasm {ECO:0000269|PubMed:9614144}. Note=DNA replication foci. Cytoplasmic in M phase.
|
![Western Blot: CHAF1B Overexpression Lysate (Adult Normal) [NBL1-09140] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for CHAF1B.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/2535_CHAF1B%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-09140-img0002.jpg)