| Gene Symbol | ESR2 |
|---|---|
| Entrez Gene | 2100 |
| Alt Symbol | ER-BETA, ESR-BETA, ESRB, ESTRB, Erb, NR3A2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | estrogen receptor 2 (ER beta) |
| Other Description | estrogen receptor beta|estrogen receptor beta 4|nuclear receptor subfamily 3 group A member 2 |
| Swissprots | O60702 Q0MWT5 Q86Z31 A8K8K5 O75584 O75583 O60685 Q92731 Q9UEV6 O60703 O60608 Q0MWT6 Q9UHD3 G3V5M5 Q9UQK9 |
| Accessions | AAG29940 AAV31779 EAW80845 EAW80846 EAW80847 EAW80848 EAW80849 EAW80850 EAW80851 EAW80852 EAW80853 EAW80854 Q92731 AB006589 BAA31966 AB006590 BAA24953 AB209620 BAD92857 AF047463 AF051427 AAC05985 AF051428 AAC05751 AF060555 AAC15234 AF061054 AAC39784 AF061055 AAC39785 AF074598 AAC25602 AF074599 AAC25603 AF124790 AAD32580 AK292370 BAF85059 AY438022 BC024181 AAH24181 BX094834 BX247957 CAD62297 CN366005 DQ777076 ABG88022 DQ777077 DQ838582 ABH09189 DQ838583 ABH09190 HG506303 HG506304 HQ692820 ADZ17331 HQ692821 ADZ17332 KC777381 KC777382 KC777383 KC777384 KC777385 KC777386 KC777387 KC777388 KJ534833 AHW56473 X99101 CAA67555 XM_011536545 XP_011534847 XM_011536546 XP_011534848 NM_001040275 NP_001035365 NM_001214902 NP_001201831 NM_001271876 NP_001258805 NM_001271877 NP_001258806 NM_001291712 NP_001278641 NM_001291723 NP_001278652 NM_001437 NP_001428 NR_073496 NR_073497 NM_001040276 NM_001214903 |
| Function | Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Isoform beta-cx lacks ligand binding ability and has no or only very low ere binding activity resulting in the loss of ligand-dependent transactivation ability. DNA- binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in the absence of ligand while in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at elevated temperature is more gradual. |
| Subcellular Location | Nucleus {ECO:0000255|PROSITE- ProRule:PRU00407, ECO:0000269|PubMed:19126643}. |
| Tissue Specificity | Isoform beta-1 is expressed in testis and ovary, and at a lower level in heart, brain, placenta, liver, skeletal muscle, spleen, thymus, prostate, colon, bone marrow, mammary gland and uterus. Also found in uterine bone, breast, and ovarian tumor cell lines, but not in colon and liver tumors. Isoform beta-2 is expressed in spleen, thymus, testis and ovary and at a lower level in skeletal muscle, prostate, colon, small intestine, leukocytes, bone marrow, mammary gland and uterus. Isoform beta-3 is found in testis. Isoform beta-4 is expressed in testis, and at a lower level in spleen, thymus, ovary, mammary gland and uterus. Isoform beta-5 is expressed in testis, placenta, skeletal muscle, spleen and leukocytes, and at a lower level in heart, lung, liver, kidney, pancreas, thymus, prostate, colon, small intestine, bone marrow, mammary gland and uterus. Not expressed in brain. |
| Top Pathways | Prolactin signaling pathway, Estrogen signaling pathway |
Human ESR2 / ER Beta ELISA Kit (Sandwich ELISA) - LS-F6364 from LifeSpan Bioscience
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Rat ESR2 / ER Beta ELISA Kit (Sandwich ELISA) - LS-F6266 from LifeSpan Bioscience
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Mouse/Human/Rat Phospho-ESR2 / ER Beta (Ser105) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1358 from LifeSpan Bioscience
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Mouse/Human/Rat ESR2 / ER Beta ELISA Kit (Cell-Based ELISA) - LS-F1977 from LifeSpan Bioscience
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Mouse/Human/Rat ESR2 / ER Beta ELISA Kit (DNA-Binding ELISA) - LS-F865 from LifeSpan Bioscience
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Mouse/Human Phospho-ESR2 / ER Beta (Ser105) ELISA Kit (DNA-Binding Phosphorylation ELISA) - LS-F864 from LifeSpan Bioscience
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Mouse ESR2 / ER Beta ELISA Kit (Sandwich ELISA) - LS-F8615 from LifeSpan Bioscience
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Human ESR2 / ER Beta ELISA Kit (Sandwich ELISA) - LS-F11397 from LifeSpan Bioscience
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Mouse ESR2 / ER Beta ELISA Kit (Sandwich ELISA) - LS-F11400 from LifeSpan Bioscience
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Pig ESR2 / ER Beta ELISA Kit (Sandwich ELISA) - LS-F11399 from LifeSpan Bioscience
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Rat ESR2 / ER Beta ELISA Kit (Sandwich ELISA) - LS-F11398 from LifeSpan Bioscience
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Human ERb ELISA Kit - abx151440 from Abbexa
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Estrogen Receptor Beta, ERb, Human, ELISA Kit - E-EL-H1132 from ARP American Research Products
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Estrogen Receptor Beta (ERb), Human, ELISA Kit - SEA437Hu from ARP American Research Products
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Estrogen receptor beta (ESR2), Human, ELISA Kit - E01E0386 from ARP American Research Products
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Estrogen receptor beta, ESR2, Human, ELISA Kit - E2300h from ARP American Research Products
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Estrogen Receptor Beta, Human, ELISA Kit - E01E0067 from ARP American Research Products
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Estrogen Receptor Beta, ERb, Mouse, ELISA Kit - E-EL-M0490 from ARP American Research Products
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Estrogen Receptor Beta, ERb, Rabbit, ELISA Kit - E-EL-RB1604 from ARP American Research Products
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Estrogen Receptor Beta, ERb, Chicken, ELISA Kit - E-EL-Ch1495 from ARP American Research Products
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Estrogen Receptor Beta, ERb, Porcine, ELISA Kit - E-EL-P0192 from ARP American Research Products
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Estrogen Receptor Beta, ERb, Sheep, ELISA Kit - E-EL-S0460 from ARP American Research Products
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Estrogen Receptor Beta, ERb, Monkey, ELISA Kit - E-EL-MK1978 from ARP American Research Products
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Estrogen Receptor Beta (ERb), Human, CLIA Kit - SCA437Hu from ARP American Research Products
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Estrogen receptor beta, ELISA Kit - MBS280357 from MyBioSource
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