ESR2
| Gene Symbol | ESR2 |
|---|---|
| Entrez Gene | 2100 |
| Alt Symbol | ER-BETA, ESR-BETA, ESRB, ESTRB, Erb, NR3A2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | estrogen receptor 2 (ER beta) |
| Other Description | estrogen receptor beta|estrogen receptor beta 4|nuclear receptor subfamily 3 group A member 2 |
| Swissprots | O60702 Q0MWT5 Q86Z31 A8K8K5 O75584 O75583 O60685 Q92731 Q9UEV6 O60703 O60608 Q0MWT6 Q9UHD3 G3V5M5 Q9UQK9 |
| Accessions | AAG29940 AAV31779 EAW80845 EAW80846 EAW80847 EAW80848 EAW80849 EAW80850 EAW80851 EAW80852 EAW80853 EAW80854 Q92731 AB006589 BAA31966 AB006590 BAA24953 AB209620 BAD92857 AF047463 AF051427 AAC05985 AF051428 AAC05751 AF060555 AAC15234 AF061054 AAC39784 AF061055 AAC39785 AF074598 AAC25602 AF074599 AAC25603 AF124790 AAD32580 AK292370 BAF85059 AY438022 BC024181 AAH24181 BX094834 BX247957 CAD62297 CN366005 DQ777076 ABG88022 DQ777077 DQ838582 ABH09189 DQ838583 ABH09190 HG506303 HG506304 HQ692820 ADZ17331 HQ692821 ADZ17332 KC777381 KC777382 KC777383 KC777384 KC777385 KC777386 KC777387 KC777388 KJ534833 AHW56473 X99101 CAA67555 XM_011536545 XP_011534847 XM_011536546 XP_011534848 NM_001040275 NP_001035365 NM_001214902 NP_001201831 NM_001271876 NP_001258805 NM_001271877 NP_001258806 NM_001291712 NP_001278641 NM_001291723 NP_001278652 NM_001437 NP_001428 NR_073496 NR_073497 NM_001040276 NM_001214903 |
| Function | Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Isoform beta-cx lacks ligand binding ability and has no or only very low ere binding activity resulting in the loss of ligand-dependent transactivation ability. DNA- binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in the absence of ligand while in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at elevated temperature is more gradual. |
| Subcellular Location | Nucleus {ECO:0000255|PROSITE- ProRule:PRU00407, ECO:0000269|PubMed:19126643}. |
| Tissue Specificity | Isoform beta-1 is expressed in testis and ovary, and at a lower level in heart, brain, placenta, liver, skeletal muscle, spleen, thymus, prostate, colon, bone marrow, mammary gland and uterus. Also found in uterine bone, breast, and ovarian tumor cell lines, but not in colon and liver tumors. Isoform beta-2 is expressed in spleen, thymus, testis and ovary and at a lower level in skeletal muscle, prostate, colon, small intestine, leukocytes, bone marrow, mammary gland and uterus. Isoform beta-3 is found in testis. Isoform beta-4 is expressed in testis, and at a lower level in spleen, thymus, ovary, mammary gland and uterus. Isoform beta-5 is expressed in testis, placenta, skeletal muscle, spleen and leukocytes, and at a lower level in heart, lung, liver, kidney, pancreas, thymus, prostate, colon, small intestine, bone marrow, mammary gland and uterus. Not expressed in brain. |
| Top Pathways | Prolactin signaling pathway, Estrogen signaling pathway |
ERβ siRNA (h) - sc-35325 from Santa Cruz Biotechnology
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ERβ shRNA Plasmid (h) - sc-35325-SH from Santa Cruz Biotechnology
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ERβ shRNA (h) Lentiviral Particles - sc-35325-V from Santa Cruz Biotechnology
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ERβ siRNA (h2) - sc-44297 from Santa Cruz Biotechnology
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ERβ shRNA Plasmid (h2) - sc-44297-SH from Santa Cruz Biotechnology
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ERβ shRNA (h2) Lentiviral Particles - sc-44297-V from Santa Cruz Biotechnology
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ER beta/NR3A2 RNAi - H00002100-R01 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN1021 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN1250 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN1251 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1250 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1251 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1021 from Sigma-Aldrich
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ESR2 siRNA (Human) - CRH1458 from Cohesion Biosciences
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ESR2 - MBS8212021 from MyBioSource
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shRNA set against Human ESR2 (NM_001437.2) - SHH287413 from Creative biogene
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shRNA set against Human ESR2(NM_001040275.1) - SHH039557 from Creative biogene
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shRNA set against Human ESR2(NM_001437.2) - SHH039593 from Creative biogene
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Human ESR2 siRNA - orb261960 from Biorbyt
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ESR2 shRNA Plasmid (Human) - CHH1458 from Cohesion Biosciences
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ESR2 miRNA 3'UTR clone - MiUTR1H-03314 from Creative biogene
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ESR2 miRNA 3'UTR clone - MiUTR3H-04302 from Creative biogene
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ESR2 miRNA 3'UTR clone - MiUTR3H-04303 from Creative biogene
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