ESR2

Gene Symbol	ESR2
Entrez Gene	2100
Alt Symbol	ER-BETA, ESR-BETA, ESRB, ESTRB, Erb, NR3A2
Species	Human
Gene Type	protein-coding
Description	estrogen receptor 2 (ER beta)
Other Description	estrogen receptor beta|estrogen receptor beta 4|nuclear receptor subfamily 3 group A member 2
Swissprots	O60702 Q0MWT5 Q86Z31 A8K8K5 O75584 O75583 O60685 Q92731 Q9UEV6 O60703 O60608 Q0MWT6 Q9UHD3 G3V5M5 Q9UQK9
Accessions	AAG29940 AAV31779 EAW80845 EAW80846 EAW80847 EAW80848 EAW80849 EAW80850 EAW80851 EAW80852 EAW80853 EAW80854 Q92731 AB006589 BAA31966 AB006590 BAA24953 AB209620 BAD92857 AF047463 AF051427 AAC05985 AF051428 AAC05751 AF060555 AAC15234 AF061054 AAC39784 AF061055 AAC39785 AF074598 AAC25602 AF074599 AAC25603 AF124790 AAD32580 AK292370 BAF85059 AY438022 BC024181 AAH24181 BX094834 BX247957 CAD62297 CN366005 DQ777076 ABG88022 DQ777077 DQ838582 ABH09189 DQ838583 ABH09190 HG506303 HG506304 HQ692820 ADZ17331 HQ692821 ADZ17332 KC777381 KC777382 KC777383 KC777384 KC777385 KC777386 KC777387 KC777388 KJ534833 AHW56473 X99101 CAA67555 XM_011536545 XP_011534847 XM_011536546 XP_011534848 NM_001040275 NP_001035365 NM_001214902 NP_001201831 NM_001271876 NP_001258805 NM_001271877 NP_001258806 NM_001291712 NP_001278641 NM_001291723 NP_001278652 NM_001437 NP_001428 NR_073496 NR_073497 NM_001040276 NM_001214903
Function	Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Isoform beta-cx lacks ligand binding ability and has no or only very low ere binding activity resulting in the loss of ligand-dependent transactivation ability. DNA- binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in the absence of ligand while in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at elevated temperature is more gradual.
Subcellular Location	Nucleus {ECO:0000255|PROSITE- ProRule:PRU00407, ECO:0000269|PubMed:19126643}.
Tissue Specificity	Isoform beta-1 is expressed in testis and ovary, and at a lower level in heart, brain, placenta, liver, skeletal muscle, spleen, thymus, prostate, colon, bone marrow, mammary gland and uterus. Also found in uterine bone, breast, and ovarian tumor cell lines, but not in colon and liver tumors. Isoform beta-2 is expressed in spleen, thymus, testis and ovary and at a lower level in skeletal muscle, prostate, colon, small intestine, leukocytes, bone marrow, mammary gland and uterus. Isoform beta-3 is found in testis. Isoform beta-4 is expressed in testis, and at a lower level in spleen, thymus, ovary, mammary gland and uterus. Isoform beta-5 is expressed in testis, placenta, skeletal muscle, spleen and leukocytes, and at a lower level in heart, lung, liver, kidney, pancreas, thymus, prostate, colon, small intestine, bone marrow, mammary gland and uterus. Not expressed in brain.
Top Pathways	Prolactin signaling pathway, Estrogen signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

ESR2 293 Cell Lysate - 400556 from ABBIOTEC Category Cell Lysate Prices $672.00 Sizes 100 µg

ER beta/NR3A2 Overexpression Lysate (Native) - NBL1-10345 from Novus Biologicals Category Cell Lysate Prices $529.00 Sizes 100 µg

ESR2 Over-expression Lysate Product - GWB-37ECAC from Genway Biotech Category Cell Lysate Prices $756.00 Sizes 100 µg Species Human

ER beta/NR3A2 Overexpression Lysate (Native) - NBP2-10628 from Novus Biologicals Category Cell Lysate Prices $529.00 Sizes 100 µg

ER beta/NR3A2 Overexpression Lysate (Native) - NBP2-11196 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

ER beta/NR3A2 Overexpression Lysate (Denatured) - H00002100-T03 from Novus Biologicals Category Cell Lysate Prices $299.00 Sizes 100 µl

Panoply™ Human ESR2 Knockdown Stable Cell Line - CSC-DC005083 from Creative biogene Category Cell Line Species Human

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