SRPK1

Gene Symbol	SRPK1
Entrez Gene	6732
Alt Symbol	SFRSK1
Species	Human
Gene Type	protein-coding
Description	SRSF protein kinase 1
Other Description	SFRS protein kinase 1|SR-protein-specific kinase 1|serine/arginine-rich splicing factor kinase 1|serine/threonine-protein kinase SRPK1
Swissprots	Q5R364 Q96SB4 Q8IY12 Q12890 Q5R365 B4DS61
Accessions	EAX03853 EAX03854 EAX03855 EAX03856 EAX03857 EAX03858 EAX03859 EAX03860 Q96SB4 AJ318054 CAC39299 AK292277 BAF84966 AK299591 BAG61523 AK312712 AL117648 BC038292 AAH38292 BG772464 BX648663 BX648697 DB233331 NM_003137 NP_003128 NR_034069
Function	Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Plays a central role in the regulatory network for splicing, controlling the intranuclear distribution of splicing factors in interphase cells and the reorganization of nuclear speckles during mitosis. Can influence additional steps of mRNA maturation, as well as other cellular activities, such as chromatin reorganization in somatic and sperm cells and cell cycle progression. Isoform 2 phosphorylates SFRS2, ZRSR2, LBR and PRM1. Isoform 2 phosphorylates SRSF1 using a directional (C-terminal to N-terminal) and a dual-track mechanism incorporating both processive phosphorylation (in which the kinase stays attached to the substrate after each round of phosphorylation) and distributive phosphorylation steps (in wh
Subcellular Location	Isoform 2: Cytoplasm. Nucleus. Nucleus matrix. Microsome. Note=Shuttles between the nucleus and the cytoplasm. Inhibition of the Hsp90 ATPase activity, osmotic stress and interaction with HHV-1 ICP27 protein can induce its translocation to the nucleus. KAT5/TIP60 inhibits its nuclear translocation.
Tissue Specificity	Isoform 2 is predominantly expressed in the testis but is also present at lower levels in heart, ovary, small intestine, liver, kidney, pancreas and skeletal muscle. Isoform 1 is only seen in the testis, at lower levels than isoform 2. Highly expressed in different erythroid and lymphoid cell lines, with isoform 2 being far more abundant than isoform 1. {ECO:0000269|PubMed:10390541, ECO:0000269|PubMed:11509566, ECO:0000269|PubMed:20708644}.
Top Pathways	Herpes simplex infection

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SRPK (D-7) - sc-398432 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

SRPK1 (EE-13) - sc-100443 from Santa Cruz Biotechnology Prices $295.00 Sizes 100 µg/ml Host Mouse Clonality Monoclonal

SRPK (A-17) - sc-11306 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

SRPK1 (H-40) - sc-50343 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

SRPK1 (P-17) - sc-11305 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-SRPK1 antibody - ab90527 from Abcam Prices $384.00 Sizes 20 µg Host Rabbit Clonality Polyclonal

Anti-SRPK1 antibody - ab58002 from Abcam Prices $384.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-SRPK1 antibody - ab189839 from Abcam Prices $376.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-SRPK1 antibody - ab118793 from Abcam Prices $376.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-SRPK1 antibody - ab113114 from Abcam Prices $359.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-SRPK1 antibody - ab138277 from Abcam Prices $376.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-SRPK1 antibody - ab58003 from Abcam Prices $376.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-SRPK1 antibody [6H5] - ab119297 from Abcam Prices $376.00 Sizes 50 µg Host Mouse Clonality Monoclonal Clone 6H5

Anti-SRPK1 antibody [EPR6915(2)] - ab131160 from Abcam Prices $379.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR6915(2)

Anti-SRPK1 Antibody (clone 6H5) IHC-plus™ - LS-B4422 from LifeSpan Bioscience Prices $450.00 Sizes 50 µg Host Mouse Clonality Monoclonal Clone 6H5

Anti-SRPK1 Antibody (N-Terminus, Azide-free, HRP) - LS-C226413 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-SRPK1 Antibody (N-Terminus, FITC) - LS-C226412 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-SRPK1 Antibody (N-Terminus, AP) - LS-C226414 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-SRPK1 Antibody (N-Terminus, APC) - LS-C226415 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-SRPK1 Antibody (N-Terminus, PE) - LS-C226416 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-SRPK1 Antibody (N-Terminus, Biotin) - LS-C226417 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-SRPK1 Antibody (aa399-448) - LS-C145405 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-SRPK1 Antibody (aa521-570) - LS-C120371 from LifeSpan Bioscience Prices $315.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-SRPK1 Antibody (Internal, clone EPR6915(2)) - LS-C154490 from LifeSpan Bioscience Prices $475.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR6915(2)

Anti-SRPK1 Antibody (N-Terminus, FITC) - LS-C226418 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

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