SRPK1

Gene Symbol	SRPK1
Entrez Gene	6732
Alt Symbol	SFRSK1
Species	Human
Gene Type	protein-coding
Description	SRSF protein kinase 1
Other Description	SFRS protein kinase 1|SR-protein-specific kinase 1|serine/arginine-rich splicing factor kinase 1|serine/threonine-protein kinase SRPK1
Swissprots	Q5R364 Q96SB4 Q8IY12 Q12890 Q5R365 B4DS61
Accessions	EAX03853 EAX03854 EAX03855 EAX03856 EAX03857 EAX03858 EAX03859 EAX03860 Q96SB4 AJ318054 CAC39299 AK292277 BAF84966 AK299591 BAG61523 AK312712 AL117648 BC038292 AAH38292 BG772464 BX648663 BX648697 DB233331 NM_003137 NP_003128 NR_034069
Function	Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Plays a central role in the regulatory network for splicing, controlling the intranuclear distribution of splicing factors in interphase cells and the reorganization of nuclear speckles during mitosis. Can influence additional steps of mRNA maturation, as well as other cellular activities, such as chromatin reorganization in somatic and sperm cells and cell cycle progression. Isoform 2 phosphorylates SFRS2, ZRSR2, LBR and PRM1. Isoform 2 phosphorylates SRSF1 using a directional (C-terminal to N-terminal) and a dual-track mechanism incorporating both processive phosphorylation (in which the kinase stays attached to the substrate after each round of phosphorylation) and distributive phosphorylation steps (in wh
Subcellular Location	Isoform 2: Cytoplasm. Nucleus. Nucleus matrix. Microsome. Note=Shuttles between the nucleus and the cytoplasm. Inhibition of the Hsp90 ATPase activity, osmotic stress and interaction with HHV-1 ICP27 protein can induce its translocation to the nucleus. KAT5/TIP60 inhibits its nuclear translocation.
Tissue Specificity	Isoform 2 is predominantly expressed in the testis but is also present at lower levels in heart, ovary, small intestine, liver, kidney, pancreas and skeletal muscle. Isoform 1 is only seen in the testis, at lower levels than isoform 2. Highly expressed in different erythroid and lymphoid cell lines, with isoform 2 being far more abundant than isoform 1. {ECO:0000269|PubMed:10390541, ECO:0000269|PubMed:11509566, ECO:0000269|PubMed:20708644}.
Top Pathways	Herpes simplex infection

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SRPK1 293T Cell Transient Overexpression Lysate(Denatured) - H00006732-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

SRPK1 overexpression lysate - LY401089 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

SRPK1 293 Cell Lysate - 401016 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

SRPK1 Overexpression Lysate (Denatured) - H00006732-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

SRPK1 Overexpression Lysate (Native) - NBL1-16455 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

SRPK1 Over-expression Lysate Product - GWB-40D9D6 from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

Human SRPK1 Insect Cell Lysate (WB positive control) - 12249-H20BL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

SRPK1 Overexpression Lysate (Denatured) - H00006732-T02 from Novus Biologicals Category Cell Lysate Prices $299.00 Sizes 100 µl

Human SRPK1 Baculovirus-Insect cells Transfected Lysate (positive control) (denatured) - orb232911 from Biorbyt Category Cell Lysate Prices $604.00 Sizes 300 μg Species Human

Panoply™ Human SRPK1 Knockdown Stable Cell Line - CSC-DC015161 from Creative biogene Category Cell Line Species Human

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