SRPK1

Gene Symbol	SRPK1
Entrez Gene	6732
Alt Symbol	SFRSK1
Species	Human
Gene Type	protein-coding
Description	SRSF protein kinase 1
Other Description	SFRS protein kinase 1|SR-protein-specific kinase 1|serine/arginine-rich splicing factor kinase 1|serine/threonine-protein kinase SRPK1
Swissprots	Q5R364 Q96SB4 Q8IY12 Q12890 Q5R365 B4DS61
Accessions	EAX03853 EAX03854 EAX03855 EAX03856 EAX03857 EAX03858 EAX03859 EAX03860 Q96SB4 AJ318054 CAC39299 AK292277 BAF84966 AK299591 BAG61523 AK312712 AL117648 BC038292 AAH38292 BG772464 BX648663 BX648697 DB233331 NM_003137 NP_003128 NR_034069
Function	Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Plays a central role in the regulatory network for splicing, controlling the intranuclear distribution of splicing factors in interphase cells and the reorganization of nuclear speckles during mitosis. Can influence additional steps of mRNA maturation, as well as other cellular activities, such as chromatin reorganization in somatic and sperm cells and cell cycle progression. Isoform 2 phosphorylates SFRS2, ZRSR2, LBR and PRM1. Isoform 2 phosphorylates SRSF1 using a directional (C-terminal to N-terminal) and a dual-track mechanism incorporating both processive phosphorylation (in which the kinase stays attached to the substrate after each round of phosphorylation) and distributive phosphorylation steps (in wh
Subcellular Location	Isoform 2: Cytoplasm. Nucleus. Nucleus matrix. Microsome. Note=Shuttles between the nucleus and the cytoplasm. Inhibition of the Hsp90 ATPase activity, osmotic stress and interaction with HHV-1 ICP27 protein can induce its translocation to the nucleus. KAT5/TIP60 inhibits its nuclear translocation.
Tissue Specificity	Isoform 2 is predominantly expressed in the testis but is also present at lower levels in heart, ovary, small intestine, liver, kidney, pancreas and skeletal muscle. Isoform 1 is only seen in the testis, at lower levels than isoform 2. Highly expressed in different erythroid and lymphoid cell lines, with isoform 2 being far more abundant than isoform 1. {ECO:0000269|PubMed:10390541, ECO:0000269|PubMed:11509566, ECO:0000269|PubMed:20708644}.
Top Pathways	Herpes simplex infection

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human SRPK1 full length protein - ab85295 from Abcam Category Protein Prices $302.00, $352.00 Sizes 5 µg, 10 µg Source Baculovirus infected sf9 cells Species Human

Human SRPK1 full length protein - ab152705 from Abcam Category Protein Source Wheat germ Species Human

Human SRPK1 protein fragment - ab152706 from Abcam Category Protein Source Wheat germ Species Human

SRPK1 Antibody Blocking Peptide - LS-E22495 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SRPK1 Antibody Blocking Peptide - LS-E9045 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SRPK1 Antibody Blocking Peptide - LS-E8628 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human SRPK1 Protein - H00006732-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human SRPK1 Protein - H00006732-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

SRPK1 Recombinant Protein - P4778 from Novus Biologicals Category Protein Prices $1,559.00 Sizes 100 µg Species Human

SRPK1 Peptide - P2127 from Novus Biologicals Category Peptide Species Human

SRPK1 Peptide - P2562 from Novus Biologicals Category Peptide Species Human

SRPK1-Antibody-N-term-Blocking-Peptide - BP7036a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SRPK1-Antibody-N-term-Blocking-Peptide - BP7552a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Human SRPK1 His GST tag protein - orb84258 from Biorbyt Category Protein Prices $323.00, $646.00 Sizes 20 μg, 100 μg Source Insect Species Human

SRPK1 Blocking Peptide - 33R-8841 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

SRPK1 - H00006732-P01-02 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Source in vitro transl. Species Human

SRPK1 - H00006732-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

SRPK1 - H00006732-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

SRPK1 - P4778 from Acris Antibodies Category Protein Prices $1,380.00 Sizes 100 µg Species Human

SRPK1 - P5770 from Acris Antibodies Category Protein Prices $840.00 Sizes 5 µg Species Human

SRPK1 fusion protein - ag4919 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

SRPK1 fusion protein - ag5149 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

Recombinant Human SFRS Protein Kinase 1, GST-His - SRPK1-713H from Creative Biomart Category Protein Source Baculovirus infected Sf9 cells.

Recombinant Human SFRS Protein Kinase 1, GST-tagged, Active - SRPK1-435H from Creative Biomart Category Protein Source Sf9 insect cells using baculovirus.

Recombinant Human SRPK1, His tagged - SRPK1-903H from Creative Biomart Category Protein Source Baculovirus-Insect Cells Species Human

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