| Gene Symbol | SRPK1 |
|---|---|
| Entrez Gene | 6732 |
| Alt Symbol | SFRSK1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | SRSF protein kinase 1 |
| Other Description | SFRS protein kinase 1|SR-protein-specific kinase 1|serine/arginine-rich splicing factor kinase 1|serine/threonine-protein kinase SRPK1 |
| Swissprots | Q5R364 Q96SB4 Q8IY12 Q12890 Q5R365 B4DS61 |
| Accessions | EAX03853 EAX03854 EAX03855 EAX03856 EAX03857 EAX03858 EAX03859 EAX03860 Q96SB4 AJ318054 CAC39299 AK292277 BAF84966 AK299591 BAG61523 AK312712 AL117648 BC038292 AAH38292 BG772464 BX648663 BX648697 DB233331 NM_003137 NP_003128 NR_034069 |
| Function | Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Plays a central role in the regulatory network for splicing, controlling the intranuclear distribution of splicing factors in interphase cells and the reorganization of nuclear speckles during mitosis. Can influence additional steps of mRNA maturation, as well as other cellular activities, such as chromatin reorganization in somatic and sperm cells and cell cycle progression. Isoform 2 phosphorylates SFRS2, ZRSR2, LBR and PRM1. Isoform 2 phosphorylates SRSF1 using a directional (C-terminal to N-terminal) and a dual-track mechanism incorporating both processive phosphorylation (in which the kinase stays attached to the substrate after each round of phosphorylation) and distributive phosphorylation steps (in wh |
| Subcellular Location | Isoform 2: Cytoplasm. Nucleus. Nucleus matrix. Microsome. Note=Shuttles between the nucleus and the cytoplasm. Inhibition of the Hsp90 ATPase activity, osmotic stress and interaction with HHV-1 ICP27 protein can induce its translocation to the nucleus. KAT5/TIP60 inhibits its nuclear translocation. |
| Tissue Specificity | Isoform 2 is predominantly expressed in the testis but is also present at lower levels in heart, ovary, small intestine, liver, kidney, pancreas and skeletal muscle. Isoform 1 is only seen in the testis, at lower levels than isoform 2. Highly expressed in different erythroid and lymphoid cell lines, with isoform 2 being far more abundant than isoform 1. {ECO:0000269|PubMed:10390541, ECO:0000269|PubMed:11509566, ECO:0000269|PubMed:20708644}. |
| Top Pathways | Herpes simplex infection |