| Gene Symbol |
MSRB2
|
| Entrez Gene |
22921
|
| Alt Symbol |
CBS-1, CBS1, CGI-131, MSRB, PILB
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
methionine sulfoxide reductase B2
|
| Other Description |
methionine-R-sulfoxide reductase B2, mitochondrial|pilin-like transcription factor
|
| Swissprots |
Q9Y3D2 Q17R44 Q9Y5W6 Q4G1C7
|
| Accessions |
ACA05998 ACA05999 EAW86133 EAW86134 EAW86135 EAW86136 Q9Y3D2 AF122004 AAD38899 AF151889 AAD34126 BC018030 AAH18030 BC066305 BC117471 AAI17472 BC130380 AAI30381 EU446941 ABZ92470 XM_011519426 XP_011517728 NM_012228 NP_036360
|
| Function |
Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases, methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post- translational modification that takes place on specific residue. Upon oxidative stress, may play a role in the preservation of mitochondrial integrity by decreasing the intracellular reactive oxygen species build-up through its scavenging role, hence contributing to cell survival and protein maintenance. {ECO:0000269|PubMed:18424444}.
|
| Subcellular Location |
Mitochondrion {ECO:0000269|PubMed:18424444}.
|
| Tissue Specificity |
Ubiquitous. Detected in retina, ocular ciliary body, skeletal muscle, heart, colon, bone marrow, cerebellum, small intestine, fetal brain, fetal liver, kidney, spinal cord, lung, placenta and prostate. {ECO:0000269|PubMed:10375640, ECO:0000269|PubMed:15914630}.
|
![Western Blot: MSRB2 Overexpression Lysate (Adult Normal) [NBL1-13337] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for MSRB2.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/4544_MSRB2%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-13337-img0002.jpg)