Gene Symbol | MSRB2 |
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Entrez Gene | 22921 |
Alt Symbol | CBS-1, CBS1, CGI-131, MSRB, PILB |
Species | Human |
Gene Type | protein-coding |
Description | methionine sulfoxide reductase B2 |
Other Description | methionine-R-sulfoxide reductase B2, mitochondrial|pilin-like transcription factor |
Swissprots | Q9Y3D2 Q17R44 Q9Y5W6 Q4G1C7 |
Accessions | ACA05998 ACA05999 EAW86133 EAW86134 EAW86135 EAW86136 Q9Y3D2 AF122004 AAD38899 AF151889 AAD34126 BC018030 AAH18030 BC066305 BC117471 AAI17472 BC130380 AAI30381 EU446941 ABZ92470 XM_011519426 XP_011517728 NM_012228 NP_036360 |
Function | Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases, methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post- translational modification that takes place on specific residue. Upon oxidative stress, may play a role in the preservation of mitochondrial integrity by decreasing the intracellular reactive oxygen species build-up through its scavenging role, hence contributing to cell survival and protein maintenance. {ECO:0000269|PubMed:18424444}. |
Subcellular Location | Mitochondrion {ECO:0000269|PubMed:18424444}. |
Tissue Specificity | Ubiquitous. Detected in retina, ocular ciliary body, skeletal muscle, heart, colon, bone marrow, cerebellum, small intestine, fetal brain, fetal liver, kidney, spinal cord, lung, placenta and prostate. {ECO:0000269|PubMed:10375640, ECO:0000269|PubMed:15914630}. |
MsrB2 CRISPR/Cas9 KO Plasmid (h) - sc-411635 from Santa Cruz Biotechnology
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MsrB2 HDR Plasmid (h) - sc-411635-HDR from Santa Cruz Biotechnology
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MsrB2 Double Nickase Plasmid (h) - sc-411635-NIC from Santa Cruz Biotechnology
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MsrB2 Double Nickase Plasmid (h2) - sc-411635-NIC-2 from Santa Cruz Biotechnology
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MsrB2 CRISPR Activation Plasmid (h) - sc-411635-ACT from Santa Cruz Biotechnology
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MsrB2 CRISPR Activation Plasmid (h2) - sc-411635-ACT-2 from Santa Cruz Biotechnology
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MsrB2 Lentiviral Activation Particles (h) - sc-411635-LAC from Santa Cruz Biotechnology
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MsrB2 Lentiviral Activation Particles (h2) - sc-411635-LAC-2 from Santa Cruz Biotechnology
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MsrB2 siRNA (h) - sc-90627 from Santa Cruz Biotechnology
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MsrB2 shRNA Plasmid (h) - sc-90627-SH from Santa Cruz Biotechnology
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MsrB2 shRNA (h) Lentiviral Particles - sc-90627-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU050621 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN14659 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND14659 from Sigma-Aldrich
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MSRB2 siRNA (Human) - CRH7874 from Cohesion Biosciences
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MSRB2 RNAi - H00022921-R01 from Novus Biologicals
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shRNA set against Human MSRB2 (NM_012228.3) - SHH345832 from Creative biogene
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shRNA set against Human MSRB2(NM_012228.3) - SHG145131 from Creative biogene
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MSRB2 shRNA Plasmid (Human) - CHH7874 from Cohesion Biosciences
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MSRB2 miRNA 3'UTR clone - MiUTR1H-06485 from Creative biogene
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