| Gene Symbol | MSRB2 |
|---|---|
| Entrez Gene | 22921 |
| Alt Symbol | CBS-1, CBS1, CGI-131, MSRB, PILB |
| Species | Human |
| Gene Type | protein-coding |
| Description | methionine sulfoxide reductase B2 |
| Other Description | methionine-R-sulfoxide reductase B2, mitochondrial|pilin-like transcription factor |
| Swissprots | Q9Y3D2 Q17R44 Q9Y5W6 Q4G1C7 |
| Accessions | ACA05998 ACA05999 EAW86133 EAW86134 EAW86135 EAW86136 Q9Y3D2 AF122004 AAD38899 AF151889 AAD34126 BC018030 AAH18030 BC066305 BC117471 AAI17472 BC130380 AAI30381 EU446941 ABZ92470 XM_011519426 XP_011517728 NM_012228 NP_036360 |
| Function | Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases, methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post- translational modification that takes place on specific residue. Upon oxidative stress, may play a role in the preservation of mitochondrial integrity by decreasing the intracellular reactive oxygen species build-up through its scavenging role, hence contributing to cell survival and protein maintenance. {ECO:0000269|PubMed:18424444}. |
| Subcellular Location | Mitochondrion {ECO:0000269|PubMed:18424444}. |
| Tissue Specificity | Ubiquitous. Detected in retina, ocular ciliary body, skeletal muscle, heart, colon, bone marrow, cerebellum, small intestine, fetal brain, fetal liver, kidney, spinal cord, lung, placenta and prostate. {ECO:0000269|PubMed:10375640, ECO:0000269|PubMed:15914630}. |