DDR2

Gene Symbol	DDR2
Entrez Gene	4921
Alt Symbol	MIG20a, NTRKR3, TKT, TYRO10
Species	Human
Gene Type	protein-coding
Description	discoidin domain receptor tyrosine kinase 2
Other Description	CD167 antigen-like family member B|cell migration-inducing protein 20|discoidin domain receptor 2|discoidin domain receptor family, member 2|discoidin domain-containing receptor 2|discoidin domain-containing receptor tyrosine kinase 2|hydroxyaryl-protein kinase|migration-inducing gene 16 protein|neurotrophic tyrosine kinase receptor related 3|neurotrophic tyrosine kinase, receptor-related 3|receptor protein-tyrosine kinase TKT|tyrosine-protein kinase TYRO10|tyrosylprotein kinase
Swissprots	Q7Z730 Q16832
Accessions	EAW90713 EAW90714 Q16832 AA148473 AF268386 AK058006 AK092374 AK093865 AK093908 AK095975 BAG53183 AK225063 AK225196 AK314388 BAG37013 AY423733 AAS00496 AY871271 AAX11427 BC052998 AAH52998 BX537651 BX640899 CAE45946 CF994640 EU832145 ACE87495 EU832238 ACE86808 X74764 CAA52777 XM_006711344 XP_006711407 XM_011509586 XP_011507888 XM_011509587 XP_011507889 XM_011509588 XP_011507890 XM_011509589 XP_011507891 NM_001014796 NP_001014796 NM_006182 NP_006173
Function	Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell differentiation, remodeling of the extracellular matrix, cell migration and cell proliferation. Required for normal bone development. Regulates osteoblast differentiation and chondrocyte maturation via a signaling pathway that involves MAP kinases and leads to the activation of the transcription factor RUNX2. Regulates remodeling of the extracellular matrix by up-regulation of the collagenases MMP1, MMP2 and MMP13, and thereby facilitates cell migration and tumor cell invasion. Promotes fibroblast migration and proliferation, and thereby contributes to cutaneous wound healing. {ECO:0000269|PubMed:16186104, ECO:0000269|PubMed:16186108, ECO:0000269|PubMed:17665456, ECO:0000269|PubMed:18201965, ECO:0000269|PubMed:20004161, ECO:0000269|PubMed:20564243, ECO:0000269|PubMed:20734453, ECO:0000269|PubMed:9659899}.
Subcellular Location	Cell membrane {ECO:0000269|PubMed:18201965, ECO:0000269|PubMed:20223752, ECO:0000269|PubMed:9659899}; Single- pass type I membrane protein {ECO:0000269|PubMed:18201965, ECO:0000269|PubMed:20223752, ECO:0000269|PubMed:9659899}.
Tissue Specificity	Detected in osteocytes, osteoblastic cells in subchondral bone, bone lining cells, tibia and cartilage (at protein level). Detected at high levels in heart and lung, and at low levels in brain, placenta, liver, skeletal muscle, pancreas, and kidney. {ECO:0000269|PubMed:17665456, ECO:0000269|PubMed:20564243, ECO:0000269|PubMed:8247548}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human DDR2 ELISA Kit (Sandwich ELISA) - LS-F9970 from LifeSpan Bioscience Category ELISA Kit Prices $650.00 Sizes 1 plate Sensitivity 1.56 ng/ml Range 1.56-100 ng/ml

Phosphotyrosine DDR2 / Discoidin domain-containing Receptor 2 ELISA Kit - RAB1007 from Sigma-Aldrich Category ELISA Kit Prices $637.00 Sizes 1 kt

Human Phospho-DDR2 DuoSet IC Economy Pack, 15 Plate - DYC6170E from R&D Systems Category ELISA Kit

Human Phospho-DDR2 DuoSet IC ELISA - DYC6170-2 from R&D Systems Category ELISA Kit Prices $329.00, $649.00, $1,395.00 Sizes 1 kit (for 2 Plates), 1 kit (for 5 Plates), 1 pack (for 15 Plates) Range 62.50 - 4,000 pg/mL

Human Phospho-DDR2 DuoSet IC, 5 Plate - DYC6170-5 from R&D Systems Category ELISA Kit

Human Total DDR2 DuoSet IC ELISA - DYC2538-2 from R&D Systems Category ELISA Kit Prices $329.00, $649.00 Sizes 1 kit (for 2 Plates), 1 kit (for 5 Plates) Range 625.00 - 40,000 pg/mL

Human Total DDR2 DuoSet IC, 5 Plate - DYC2538-5 from R&D Systems Category ELISA Kit

Human DDR2 ELISA Kit - abx151268 from Abbexa Category ELISA Kit Sensitivity 0.63 ng/ml Range 1.563 ng/ml - 100 ng/ml

Discoidin domain-containing receptor 2, DDR2, Human, ELISA Kit - E1505h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t Range 0.156-10 ng/ml

Discoidin Domain Receptor Family, Member 2 (DDR2), ELISA Kit - MBS2025073 from MyBioSource Category ELISA Kit Prices $345.00, $515.00, $695.00, $2,840.00, $5,180.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity Typically less than 0.63ng/mL. Range 1.56-100ng/mL

discoidin domain receptor tyrosine kinase 2, ELISA Kit - MBS9330713 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

ELISA Kit for Discoidin Domain Receptor Family, Member 2 (DDR2) - SEA974Hu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.63ng/mL. Range 1.56-100ng/mL The standard curve concentrations used for the ELISA’s were 100ng/mL, 50ng/mL, 25ng/mL, 12.5ng/mL, 6.25ng/mL, 3.13ng/mL, 1.56ng/mL

ELISA Kit for Discoidin Domain Receptor Family, Member 2 (DDR2) - SEA974Hu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.63ng/mL. Range 1.563-100ng/mL The standard curve concentrations used for the ELISA's were 100ng/mL, 50ng/mL, 25ng/mL, 12.5ng/mL, 6.25ng/mL, 3.125ng/mL, 1.563ng/mL

Mouse DDR2 ELISA Kit (Custom ELISA) - LS-F17721 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 1.56-100 ng/ml

Human DDR2 ELISA Kit (Custom ELISA) - LS-F17722 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 1.56-100 ng/ml

Human Discoidin Domain Receptor Family, Member 2 (DDR2) ELISA Kit - EKU03759 from Biomatik Category ELISA Kit Prices $662.00, $2,944.00, $5,358.00 Sizes 96 t, 5x96t, 10x96t Sensitivity 0.63 ng/mL Range 1.56-100 ng/mL

Human Discoidin domain-containing receptor 2 ELISA Kit - abx251042 from Abbexa Category ELISA Kit Range 0.156 ng/ml - 10 ng/ml

Human Discoidin domain-containing receptor 2 ELISA Kit - EKE53938 from Biomatik Category ELISA Kit Prices $685.40, $2,912.95, $5,483.20 Sizes 96 t, 5x96t, 10x96t Sensitivity The minimum detectable dose of this kit is typically less than 0.078 ng/mL Range 0.156-10 ng/ml

DDR2 - EKH3478 from Nordic BioSite Sensitivity 0.094ng/ml Range 0.156-10ng/ml

Custom Human DDR2 ELISA - ELH-DDR2-1 from RayBiotech Category ELISA Kit Prices $627.00, $1,128.60, $2,508.00 Sizes 1 plate kit, 2 plate kit, 5 plate kit

Human Phospho-DDR2 (Tyr740) ELISA - PEL-DDR2-Y740-1 from RayBiotech Category ELISA Kit Prices $491.00, $883.80, $1,964.00 Sizes 1 plate kit, 2 plate kit, 5 plate kit

Human Phospho-DDR2 (Tyr740) and Total DDR2 ELISA - PEL-DDR2-Y740-T-1 from RayBiotech Category ELISA Kit Prices $536.00, $964.80, $2,144.00 Sizes 1 plate kit, 2 plate kit, 5 plate kit

Custom Human Phosphotyrosine TYRO10 ELISA - PEL-TYRO10-Y-1 from RayBiotech Category ELISA Kit Prices $615.00, $1,107.00, $2,460.00 Sizes 1 plate kit, 2 plate kit, 5 plate kit

Custom Human DDR2 ELISA Kit - orb384544 from Biorbyt Category ELISA Kit Prices $1,411.00, $2,448.00, $5,321.00 Sizes 96 assays, 192 assays, 480 assays

Human DDR2 (Phospho-Tyr740) ELISA Kit - orb384972 from Biorbyt Category ELISA Kit Prices $1,122.00, $1,938.00, $4,182.00 Sizes 96 assays, 192 assays, 480 assays

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