| Gene Symbol |
DDR2
|
| Entrez Gene |
4921
|
| Alt Symbol |
MIG20a, NTRKR3, TKT, TYRO10
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
discoidin domain receptor tyrosine kinase 2
|
| Other Description |
CD167 antigen-like family member B|cell migration-inducing protein 20|discoidin domain receptor 2|discoidin domain receptor family, member 2|discoidin domain-containing receptor 2|discoidin domain-containing receptor tyrosine kinase 2|hydroxyaryl-protein kinase|migration-inducing gene 16 protein|neurotrophic tyrosine kinase receptor related 3|neurotrophic tyrosine kinase, receptor-related 3|receptor protein-tyrosine kinase TKT|tyrosine-protein kinase TYRO10|tyrosylprotein kinase
|
| Swissprots |
Q7Z730 Q16832
|
| Accessions |
EAW90713 EAW90714 Q16832 AA148473 AF268386 AK058006 AK092374 AK093865 AK093908 AK095975 BAG53183 AK225063 AK225196 AK314388 BAG37013 AY423733 AAS00496 AY871271 AAX11427 BC052998 AAH52998 BX537651 BX640899 CAE45946 CF994640 EU832145 ACE87495 EU832238 ACE86808 X74764 CAA52777 XM_006711344 XP_006711407 XM_011509586 XP_011507888 XM_011509587 XP_011507889 XM_011509588 XP_011507890 XM_011509589 XP_011507891 NM_001014796 NP_001014796 NM_006182 NP_006173
|
| Function |
Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell differentiation, remodeling of the extracellular matrix, cell migration and cell proliferation. Required for normal bone development. Regulates osteoblast differentiation and chondrocyte maturation via a signaling pathway that involves MAP kinases and leads to the activation of the transcription factor RUNX2. Regulates remodeling of the extracellular matrix by up-regulation of the collagenases MMP1, MMP2 and MMP13, and thereby facilitates cell migration and tumor cell invasion. Promotes fibroblast migration and proliferation, and thereby contributes to cutaneous wound healing. {ECO:0000269|PubMed:16186104, ECO:0000269|PubMed:16186108, ECO:0000269|PubMed:17665456, ECO:0000269|PubMed:18201965, ECO:0000269|PubMed:20004161, ECO:0000269|PubMed:20564243, ECO:0000269|PubMed:20734453, ECO:0000269|PubMed:9659899}.
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:18201965, ECO:0000269|PubMed:20223752, ECO:0000269|PubMed:9659899}; Single- pass type I membrane protein {ECO:0000269|PubMed:18201965, ECO:0000269|PubMed:20223752, ECO:0000269|PubMed:9659899}.
|
| Tissue Specificity |
Detected in osteocytes, osteoblastic cells in subchondral bone, bone lining cells, tibia and cartilage (at protein level). Detected at high levels in heart and lung, and at low levels in brain, placenta, liver, skeletal muscle, pancreas, and kidney. {ECO:0000269|PubMed:17665456, ECO:0000269|PubMed:20564243, ECO:0000269|PubMed:8247548}.
|
