DDR2

Gene Symbol	DDR2
Entrez Gene	4921
Alt Symbol	MIG20a, NTRKR3, TKT, TYRO10
Species	Human
Gene Type	protein-coding
Description	discoidin domain receptor tyrosine kinase 2
Other Description	CD167 antigen-like family member B|cell migration-inducing protein 20|discoidin domain receptor 2|discoidin domain receptor family, member 2|discoidin domain-containing receptor 2|discoidin domain-containing receptor tyrosine kinase 2|hydroxyaryl-protein kinase|migration-inducing gene 16 protein|neurotrophic tyrosine kinase receptor related 3|neurotrophic tyrosine kinase, receptor-related 3|receptor protein-tyrosine kinase TKT|tyrosine-protein kinase TYRO10|tyrosylprotein kinase
Swissprots	Q7Z730 Q16832
Accessions	EAW90713 EAW90714 Q16832 AA148473 AF268386 AK058006 AK092374 AK093865 AK093908 AK095975 BAG53183 AK225063 AK225196 AK314388 BAG37013 AY423733 AAS00496 AY871271 AAX11427 BC052998 AAH52998 BX537651 BX640899 CAE45946 CF994640 EU832145 ACE87495 EU832238 ACE86808 X74764 CAA52777 XM_006711344 XP_006711407 XM_011509586 XP_011507888 XM_011509587 XP_011507889 XM_011509588 XP_011507890 XM_011509589 XP_011507891 NM_001014796 NP_001014796 NM_006182 NP_006173
Function	Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell differentiation, remodeling of the extracellular matrix, cell migration and cell proliferation. Required for normal bone development. Regulates osteoblast differentiation and chondrocyte maturation via a signaling pathway that involves MAP kinases and leads to the activation of the transcription factor RUNX2. Regulates remodeling of the extracellular matrix by up-regulation of the collagenases MMP1, MMP2 and MMP13, and thereby facilitates cell migration and tumor cell invasion. Promotes fibroblast migration and proliferation, and thereby contributes to cutaneous wound healing. {ECO:0000269|PubMed:16186104, ECO:0000269|PubMed:16186108, ECO:0000269|PubMed:17665456, ECO:0000269|PubMed:18201965, ECO:0000269|PubMed:20004161, ECO:0000269|PubMed:20564243, ECO:0000269|PubMed:20734453, ECO:0000269|PubMed:9659899}.
Subcellular Location	Cell membrane {ECO:0000269|PubMed:18201965, ECO:0000269|PubMed:20223752, ECO:0000269|PubMed:9659899}; Single- pass type I membrane protein {ECO:0000269|PubMed:18201965, ECO:0000269|PubMed:20223752, ECO:0000269|PubMed:9659899}.
Tissue Specificity	Detected in osteocytes, osteoblastic cells in subchondral bone, bone lining cells, tibia and cartilage (at protein level). Detected at high levels in heart and lung, and at low levels in brain, placenta, liver, skeletal muscle, pancreas, and kidney. {ECO:0000269|PubMed:17665456, ECO:0000269|PubMed:20564243, ECO:0000269|PubMed:8247548}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

DDR2 Antibody - 12133 from Cell Signaling Technology Prices $246.00 Sizes 100 µl (10 western blots) Host Rabbit Clonality Polyclonal

DDR2 (N-20) - sc-7555 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

DDR2 (H-108) - sc-8989 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

DDR2 (3B11E4) - sc-81707 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

Anti-DDR2 antibody - ab76967 from Abcam Prices $378.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-DDR2 antibody - ab82856 from Abcam Prices $378.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-DDR2 antibody - ab5520 from Abcam Prices $382.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-DDR2 antibody - ab154240 from Abcam Prices $376.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-DDR2 antibody [3B11E4] - ab63337 from Abcam Prices $394.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 3B11E4

Anti-DDR2 antibody [EPR5179(2)] - ab126773 from Abcam Prices $379.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR5179(2)

Anti-DDR2 Antibody (aa816-843, AP) - LS-C255958 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-DDR2 Antibody (aa816-843, APC) - LS-C255959 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-DDR2 Antibody (aa816-843, Biotin) - LS-C255960 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-DDR2 Antibody (aa816-843, FITC) - LS-C255961 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-DDR2 Antibody (aa816-843, Azide-free, HRP) - LS-C255962 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-DDR2 Antibody (aa816-843, PE) - LS-C255964 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-DDR2 Antibody (aa290-320) - LS-C159445 from LifeSpan Bioscience Prices $295.00 Sizes 100 µl Host Mouse Clonality Monoclonal

Anti-DDR2 Antibody (aa304-320, AP) - LS-C276675 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-DDR2 Antibody (aa304-320, APC) - LS-C276676 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-DDR2 Antibody (aa304-320, Biotin) - LS-C276677 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-DDR2 Antibody (C-Terminus, clone EPR5179(2)) - LS-C152287 from LifeSpan Bioscience Prices $475.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR5179(2)

Anti-DDR2 Antibody (aa290-320) - LS-C99150 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-DDR2 Antibody (aa304-320, FITC) - LS-C276678 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-DDR2 Antibody (aa304-320, Azide-free, HRP) - LS-C276679 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-DDR2 Antibody IHC-plus™ - LS-B3466 from LifeSpan Bioscience Prices $395.00 Sizes 50 µl Host Mouse Clonality Monoclonal

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