DDR2

Gene Symbol	DDR2
Entrez Gene	4921
Alt Symbol	MIG20a, NTRKR3, TKT, TYRO10
Species	Human
Gene Type	protein-coding
Description	discoidin domain receptor tyrosine kinase 2
Other Description	CD167 antigen-like family member B|cell migration-inducing protein 20|discoidin domain receptor 2|discoidin domain receptor family, member 2|discoidin domain-containing receptor 2|discoidin domain-containing receptor tyrosine kinase 2|hydroxyaryl-protein kinase|migration-inducing gene 16 protein|neurotrophic tyrosine kinase receptor related 3|neurotrophic tyrosine kinase, receptor-related 3|receptor protein-tyrosine kinase TKT|tyrosine-protein kinase TYRO10|tyrosylprotein kinase
Swissprots	Q7Z730 Q16832
Accessions	EAW90713 EAW90714 Q16832 AA148473 AF268386 AK058006 AK092374 AK093865 AK093908 AK095975 BAG53183 AK225063 AK225196 AK314388 BAG37013 AY423733 AAS00496 AY871271 AAX11427 BC052998 AAH52998 BX537651 BX640899 CAE45946 CF994640 EU832145 ACE87495 EU832238 ACE86808 X74764 CAA52777 XM_006711344 XP_006711407 XM_011509586 XP_011507888 XM_011509587 XP_011507889 XM_011509588 XP_011507890 XM_011509589 XP_011507891 NM_001014796 NP_001014796 NM_006182 NP_006173
Function	Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell differentiation, remodeling of the extracellular matrix, cell migration and cell proliferation. Required for normal bone development. Regulates osteoblast differentiation and chondrocyte maturation via a signaling pathway that involves MAP kinases and leads to the activation of the transcription factor RUNX2. Regulates remodeling of the extracellular matrix by up-regulation of the collagenases MMP1, MMP2 and MMP13, and thereby facilitates cell migration and tumor cell invasion. Promotes fibroblast migration and proliferation, and thereby contributes to cutaneous wound healing. {ECO:0000269|PubMed:16186104, ECO:0000269|PubMed:16186108, ECO:0000269|PubMed:17665456, ECO:0000269|PubMed:18201965, ECO:0000269|PubMed:20004161, ECO:0000269|PubMed:20564243, ECO:0000269|PubMed:20734453, ECO:0000269|PubMed:9659899}.
Subcellular Location	Cell membrane {ECO:0000269|PubMed:18201965, ECO:0000269|PubMed:20223752, ECO:0000269|PubMed:9659899}; Single- pass type I membrane protein {ECO:0000269|PubMed:18201965, ECO:0000269|PubMed:20223752, ECO:0000269|PubMed:9659899}.
Tissue Specificity	Detected in osteocytes, osteoblastic cells in subchondral bone, bone lining cells, tibia and cartilage (at protein level). Detected at high levels in heart and lung, and at low levels in brain, placenta, liver, skeletal muscle, pancreas, and kidney. {ECO:0000269|PubMed:17665456, ECO:0000269|PubMed:20564243, ECO:0000269|PubMed:8247548}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human DDR2 (mutated T654 M) protein fragment - ab179952 from Abcam Category Protein Prices $251.00 Sizes 5 µg Source Baculovirus infected sf9 cells Species Human

Active human DDR2 protein fragment - ab96401 from Abcam Category Protein Prices $294.00 Sizes 10 µg Source Baculovirus Species Human

Human DDR2 full length protein - ab131983 from Abcam Category Protein Source Wheat germ Species Human

Human DDR2 peptide - ab86427 from Abcam Category Peptide

Human DDR2 protein fragment - ab152581 from Abcam Category Protein Source Wheat germ Species Human

DDR2 Antibody Blocking Peptide - LS-E3437 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

DDR2 Antibody Blocking Peptide - LS-E9193 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

DDR2 Partial Recombinant Protein - H00004921-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

DDR2 Recombinant Protein - H00004921-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg

DDR2 Recombinant Protein - P4242 from Novus Biologicals Category Protein Prices $549.00 Sizes 5 µg Species Human

DDR2 Recombinant Protein - P4675 from Novus Biologicals Category Protein Prices $1,559.00 Sizes 100 µg Species Human

Recombinant DDR2 Protein - NBP1-99508 from Novus Biologicals Category Protein Prices $295.00 Sizes 5 µg Source Baculovirus (Sf9 insect cells)

DDR2 Recombinant Protein - H00004921-G01 from Novus Biologicals Category Protein Prices $579.00 Sizes 10 µg Species Human

DDR2-TYRO10-Antibody-Blocking-peptide - BP7689a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

DDR2 (Active) recombinant protein - GTX65191 from GeneTex Category Protein Prices $329.00 Sizes 5 μg Source Baculovirus (Sf9 insect cells) Species Human

Recombinant Human DDR2, CF - 2538-DR-050 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived, Gln24-Arg399, with a C-terminal 6-His tag

Human CD167b protein - orb138695 from Biorbyt Category Protein Prices $323.00, $400.00 Sizes 20 μg, 10 μg Source Baculovirus-Insect Cells Species Human

Human DDR2 Fc tag protein - orb82966 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 50 μg, 100 μg Source Human Species Human

CD167b / DDR2 - H00004921-G01 from Acris Antibodies Category Protein Prices $550.00 Sizes 10 µg Species Human

CD167b / DDR2 - H00004921-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

CD167b / DDR2 - H00004921-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

CD167b / DDR2 - H00004921-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

CD167b / DDR2 - H00004921-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

CD167b / DDR2 - P4242 from Acris Antibodies Category Protein Prices $670.00 Sizes 5 µg Species Human

CD167b / DDR2 - P4675 from Acris Antibodies Category Protein Prices $1,380.00 Sizes 100 µg Species Human

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