RBL1

Gene Symbol RBL1
Entrez Gene 5933
Alt Symbol CP107, PRB1, p107
Species Human
Gene Type protein-coding
Description retinoblastoma-like 1
Other Description 107 kDa retinoblastoma-associated protein|cellular protein 107|retinoblastoma-like 1 (p107)|retinoblastoma-like protein 1
Swissprots A8K2W5 P28749 Q9H1M1 Q9H1L5 Q8N5K6 Q4VXA0
Accessions AAD14290 EAW76088 EAW76089 P28749 AK290380 BAF83069 AK308096 AK310870 BC032247 AAH32247 BQ004524 CB115117 DQ890612 ABM92229 DQ893783 ABM84709 L14812 AAA02489 M74547 AAA36397 XM_006723842 XP_006723905 XM_011528955 XP_011527257 XM_011528956 XP_011527258 XM_011528957 XP_011527259 XM_011528958 XP_011527260 XM_011528959 XP_011527261 NM_002895 NP_002886 NM_183404 NP_899662
Function Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation. Forms a complex with adenovirus E1A and with SV40 large T antigen. May bind and modulate functionally certain cellular proteins with which T and E1A compete for pocket binding. May act as a tumor suppressor.
Subcellular Location Nucleus {ECO:0000305}.
Top Pathways Cell cycle, TGF-beta signaling pathway, Viral carcinogenesis

p107 (SD9) - sc-250 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
p107 (SD9): sc-250. Western blot analysis of p107 expression in NIH/3T3 (A) and KNRK (B) cell extracts.

p107 (H-117) - sc-8345 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

p107 (C-18) - sc-318 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
p107 (C-18): sc-318-G. Western blot analysis of p107 expression in C32 (A), MM-142 (B) and KNRK (C) whole cell lysates.

p107 (D-14) - sc-30540 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

p107 (K-14) - sc-30541 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

p-p107 (Ser 975) - sc-130209 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
p-p107 (Ser 975): sc-130209. Immunoperoxidase staining of formalin fixed, paraffin-embedded human cancer tissue showing cytoplasmic staining.

Anti-p107 (phospho T369) antibody - ab111348 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab111348 at 1/50 dilution staining p107 in paraffin-embedded Human Lymph node tissue by Immunohistochemistry. The image on the right is treated with the synthesized phosphopeptide.

Anti-p107 antibody - ab2451 from Abcam

Prices $373.00
Sizes 1 ml
Host Rabbit
Clonality Polyclonal

Anti-p107 antibody - ab90507 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-p107 antibody (ab90507) at 1 µg/ml + COLO205 cell lysate at 10 µgSecondaryanti-Rabbit IgG HRP at 1/50000 dilution

Anti-p107 antibody - ab168458 from Abcam

Prices $376.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-p107 antibody (ab168458) at 1 µg/mlLane 1 : Lysate from 293T cells transfected with p107Lane 2 : Non-transfected 293T cell lysateLysates/proteins at 15 µl per lane.developed using the ECL technique

Anti-p107 antibody - ab59532 from Abcam

Prices $370.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-RBL1 / p107 Antibody (aa1048-1068) - LS-C313031 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
RBL1 / p107 antibody. IHC(P): Rat Intestine Tissue.

Anti-RBL1 / p107 Antibody (phospho-Ser975) - LS-C96954 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.

Anti-RBL1 / p107 Antibody (N-Terminus) - LS-C26518 from LifeSpan Bioscience

Prices $330.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-RBL1 / p107 Antibody (C-Terminus) - LS-C51722 from LifeSpan Bioscience

Prices $295.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-RBL1 / p107 Antibody (aa335-384) - LS-C117822 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence of NIH-3T3 cells, using RBL1 (Ab-369) Antibody. The picture on the right is treated with the synthesized peptide.

Anti-RBL1 / p107 Antibody (phospho-Thr369) - LS-C199522 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
IHC of paraffin-embedded human lymph node, using RBL1 (Phospho-Thr369) Antibody. The sample on the right was incubated with synthetic peptide.

Anti-RBL1 / p107 Antibody (aa1007-1035, AP) - LS-C267904 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-RBL1 / p107 Antibody (aa143-192) - LS-C112339 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
RBL1 / p107 antibody LS-C112339 Western blot of COLO205 cell lysate.

Anti-RBL1 / p107 Antibody (aa1007-1035, APC) - LS-C267905 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-RBL1 / p107 Antibody (aa935-984) - LS-C109673 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
RBL1 / p107 antibody LS-C109673 Western blot of Fetal Muscle lysate.

Anti-RBL1 / p107 Antibody (aa1007-1035, Biotin) - LS-C267906 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-RBL1 / p107 Antibody (clone 1A5) - LS-C198066 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1A5
Western Blot analysis of RBL1 expression in transfected 293T cell line by RBL1 monoclonal antibody (M01), clone 1A5.Lane 1: RBL1 transfected lysate (Predicted MW: 111.54 KDa).Lane 2: Non-transfected lysate.

Anti-RBL1 / p107 Antibody (aa1007-1035, FITC) - LS-C267907 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-RBL1 / p107 Antibody (aa1007-1035, Azide-free, HRP) - LS-C267908 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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