| Gene Symbol |
RBL1
|
| Entrez Gene |
5933
|
| Alt Symbol |
CP107, PRB1, p107
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
retinoblastoma-like 1
|
| Other Description |
107 kDa retinoblastoma-associated protein|cellular protein 107|retinoblastoma-like 1 (p107)|retinoblastoma-like protein 1
|
| Swissprots |
A8K2W5 P28749 Q9H1M1 Q9H1L5 Q8N5K6 Q4VXA0
|
| Accessions |
AAD14290 EAW76088 EAW76089 P28749 AK290380 BAF83069 AK308096 AK310870 BC032247 AAH32247 BQ004524 CB115117 DQ890612 ABM92229 DQ893783 ABM84709 L14812 AAA02489 M74547 AAA36397 XM_006723842 XP_006723905 XM_011528955 XP_011527257 XM_011528956 XP_011527258 XM_011528957 XP_011527259 XM_011528958 XP_011527260 XM_011528959 XP_011527261 NM_002895 NP_002886 NM_183404 NP_899662
|
| Function |
Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation. Forms a complex with adenovirus E1A and with SV40 large T antigen. May bind and modulate functionally certain cellular proteins with which T and E1A compete for pocket binding. May act as a tumor suppressor.
|
| Subcellular Location |
Nucleus {ECO:0000305}.
|
| Top Pathways |
Cell cycle, TGF-beta signaling pathway, Viral carcinogenesis
|