RBL1

Gene Symbol	RBL1
Entrez Gene	5933
Alt Symbol	CP107, PRB1, p107
Species	Human
Gene Type	protein-coding
Description	retinoblastoma-like 1
Other Description	107 kDa retinoblastoma-associated protein|cellular protein 107|retinoblastoma-like 1 (p107)|retinoblastoma-like protein 1
Swissprots	A8K2W5 P28749 Q9H1M1 Q9H1L5 Q8N5K6 Q4VXA0
Accessions	AAD14290 EAW76088 EAW76089 P28749 AK290380 BAF83069 AK308096 AK310870 BC032247 AAH32247 BQ004524 CB115117 DQ890612 ABM92229 DQ893783 ABM84709 L14812 AAA02489 M74547 AAA36397 XM_006723842 XP_006723905 XM_011528955 XP_011527257 XM_011528956 XP_011527258 XM_011528957 XP_011527259 XM_011528958 XP_011527260 XM_011528959 XP_011527261 NM_002895 NP_002886 NM_183404 NP_899662
Function	Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation. Forms a complex with adenovirus E1A and with SV40 large T antigen. May bind and modulate functionally certain cellular proteins with which T and E1A compete for pocket binding. May act as a tumor suppressor.
Subcellular Location	Nucleus {ECO:0000305}.
Top Pathways	Cell cycle, TGF-beta signaling pathway, Viral carcinogenesis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human p107 protein fragment - ab152652 from Abcam Category Protein Source Wheat germ Species Human

p107 peptide - ab2452 from Abcam Category Peptide

RBL1 / p107 Antibody Blocking Peptide - LS-E10799 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RBL1 / p107 Blocking Peptide - LS-E7310 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RBL1 / p107 Antibody Blocking Peptide - LS-E11395 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RBL1 / p107 Antibody Blocking Peptide - LS-E6605 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human p107 Protein - H00005933-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

p107 Peptide - P1399 from Novus Biologicals Category Peptide Species Human

RBL1-AntibodyC-term-Blocking-peptide - BP19390b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Phospho-Rb-like-1S975-Antibody-Blocking-peptide - BP3232a from Abgent, a WuXi AppTec company Category Peptide Prices $120.00 Sizes 100 µg

p107 peptide - GTX22452 from GeneTex Category Peptide Prices $179.00 Sizes 500 μl Species Human

p107 Blocking Peptide - abx161191 from Abbexa Category Peptide Species Human, Mouse, Rat

RBL1 - H00005933-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

RBL1 - H00005933-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

RBL1 fusion protein - Ag4146 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human RBL1, GST-tagged - RBL1-2204H from Creative Biomart Category Protein Source E.coli Species Human

p107 Blocking Peptide - CBP3690 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat

Recombinant Human Retinoblastoma-like protein 1(RBL1) ,partial - CSB-YP019398HU CSB-EP019398HU CSB-BP019398HU CSB-MP019398HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

p107 (374-490) - sc-4275 WB from Santa Cruz Biotechnology Category Protein Prices $88.00 Sizes 10 µg/0.1 ml Species Human

p107, Peptide - MBS443044 from MyBioSource Category Peptide Prices $125.00 Sizes 100 µg

p107 Recombinant Protein Antigen - NBP2-33791PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

p107 Protein - NBP2-33735PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Species Human

RBL1 Peptide, Human - M34GP13039H from Creative Peptides Category Peptide Source Synthetic. Species Human

Retinoblastoma-like protein 1 (RBL1), partial, Recombinant Protein - MBS966479 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

RBL1 fusion protein - Ag23612 from Proteintech Group Category Protein Source E. coli -derived, PET28a Species Human

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