TRPV3

Gene Symbol TRPV3
Entrez Gene 162514
Alt Symbol OLMS, VRL3
Species Human
Gene Type protein-coding
Description transient receptor potential cation channel, subfamily V, member 3
Other Description VRL-3|transient receptor potential cation channel subfamily V member 3|vanilloid receptor-like 3|vanilloid receptor-related osmotically activated channel protein
Swissprots Q8NFH2 Q8NDW7 Q8NET9 Q8NET8
Accessions EAW90502 EAW90503 EAW90504 EAW90505 Q8NET8 AF514998 AAM54027 AJ487035 CAD31711 AK074032 BAB84858 AK092557 AK127330 BAG54484 AK127726 BAG54559 AK304768 BAG65523 AY118267 AAM80558 AY118268 AAM80559 BC104866 AAI04867 BC104868 AAI04869 BC143294 AAI43295 BC143295 BC143299 AAI43300 BC143330 AAI43331 BC143333 BC143334 BC143336 BX537539 EU295940 ACA81614 XM_011523693 XP_011521995 XM_011523694 XP_011521996 XM_011523695 XP_011521997 XR_934004 NM_001258205 NP_001245134 NM_145068 NP_659505
Function Putative receptor-activated non-selective calcium permeant cation channel. It is activated by innocuous (warm) temperatures and shows an increased response at noxious temperatures greater than 39 degrees Celsius. Activation exhibits an outward rectification. May associate with TRPV1 and may modulate its activity. Is a negative regulator of hair growth and cycling: TRPV3-coupled signaling suppresses keratinocyte proliferation in hair follicles and induces apoptosis and premature hair follicle regression (catagen). {ECO:0000269|PubMed:12077604, ECO:0000269|PubMed:12077606, ECO:0000269|PubMed:21593771}.
Subcellular Location Membrane; Multi-pass membrane protein.
Tissue Specificity Abundantly expressed in CNS. Widely expressed at low levels. Detected in dorsal root ganglion (at protein level). Expressed in the keratinocyte layers of the outer root sheath and, to lesser extent, to the matrix of the hair follicles (at protein level). {ECO:0000269|PubMed:12077604, ECO:0000269|PubMed:12077606, ECO:0000269|PubMed:21593771}.
Top Pathways Inflammatory mediator regulation of TRP channels

TRPV3 Antibody - 3484 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from SH-SY5Y cells and mouse brain using TRPV3 Antibody.

TRPV3 (K-16) - sc-23372 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
TRPV3 (K-16): sc-23372. Western blot analysis of TRPV3 expression in HL-60 (A) and T98G (B) whole cell lysates.

TRPV3 (H-150) - sc-50414 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

TRPV3 (C-12) - sc-23373 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-TRPV3 antibody - ab32734 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
IHC image of TRPV3 staining in Human normal hippocampus formalin fixed paraffin embedded tissue section, performed on a Leica Bond™ system using the standard protocol F. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH6, epitope retrieval solution 1) for 20 mins. The section was then incubated with ab32734, 1µg/ml, for 15 mins at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. For other IHC staining systems (automated and non-automated) customers should optimize variable parameters such as antigen retrieval conditions, primary antibody concentration and antibody incubation times.

Anti-TRPV3 antibody - ab63148 from Abcam

Host Rabbit
Clonality Polyclonal

Anti-TRPV3 antibody - ab101695 from Abcam

Host Rabbit
Clonality Polyclonal

Anti-TRPV3 antibody - ab74856 from Abcam

Host Rabbit
Clonality Polyclonal

Anti-TRPV3 antibody - ab101698 from Abcam

Host Goat
Clonality Polyclonal

Anti-TRPV3 antibody [S15-39] - ab94582 from Abcam

Prices $378.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S15-39
Overlay histogram showing SH-SY5Y cells stained with ab94582 (red line). The cells were fixed with 4% paraformaldehyde (10 min) and incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab94582, 1μg/1x106 cells) for 30 min at 22°C. The secondary antibody used was Alexa Fluor® 488 goat anti-mouse IgG (H+L) (ab150113) at 1/2000 dilution for 30 min at 22°C. Isotype control antibody (black line) was mouse IgG2a [ICIGG2A] (ab91361, 1μg/1x106 cells) used under the same conditions. Unlabelled sample (blue line) was also used as a control. Acquisition of >5,000 events were collected using a 20mW Argon ion laser (488nm) and 525/30 bandpass filter. This antibody gave a positive result in 80% methanol (5 min) fixed SH-SY5Y cells used under the same conditions. Please note that Abcam do not have any data for use of this antibody on non-fixed cells. We welcome any customer feedback.

Anti-TRPV3 antibody [S15-39] - ab136879 from Abcam

Prices $378.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone S15-39
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human colon (ganglion) tissue labelling TRPV3 with ab136879 at 10µg/ml.

Anti-TRPV3 Antibody (aa458-474, clone S15-39, Biotin) - LS-C227741 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S15-39

Anti-TRPV3 Antibody (aa458-474, clone S15-39, APC) - LS-C227742 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S15-39

Anti-TRPV3 Antibody (aa458-474, clone S15-39, FITC) - LS-C227744 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S15-39

Anti-TRPV3 Antibody (aa458-474, clone S15-39, PE, Atto 594) - LS-C227745 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S15-39

Anti-TRPV3 Antibody (aa90-119) - LS-C98134 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin-embedded human testis tissue reacted with TRPV3 Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

Anti-TRPV3 Antibody (aa458-474, clone S15-39, SA) - LS-C227749 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S15-39

Anti-TRPV3 Antibody (aa458-474, clone S15-39, PerCP) - LS-C227746 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S15-39

Anti-TRPV3 Antibody (C-Terminus, AP) - LS-C246248 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TRPV3 Antibody (aa458-474, clone S15-39, RPE) - LS-C227748 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S15-39

Anti-TRPV3 Antibody (aa662-692) IHC-plus™ - LS-B7773 from LifeSpan Bioscience

Prices $395.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
Anti-TRPV3 antibody IHC of human brain, cerebellum, Purkinje. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B7773 dilution 10 ug/ml.

Anti-TRPV3 Antibody (C-Terminus, Biotin) - LS-C246249 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TRPV3 Antibody (C-Terminus, APC) - LS-C246250 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TRPV3 Antibody (C-Terminus, PE) - LS-C246252 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TRPV3 Antibody (C-Terminus, FITC) - LS-C246251 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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