TRPV3

Gene Symbol	TRPV3
Entrez Gene	162514
Alt Symbol	OLMS, VRL3
Species	Human
Gene Type	protein-coding
Description	transient receptor potential cation channel, subfamily V, member 3
Other Description	VRL-3|transient receptor potential cation channel subfamily V member 3|vanilloid receptor-like 3|vanilloid receptor-related osmotically activated channel protein
Swissprots	Q8NFH2 Q8NDW7 Q8NET9 Q8NET8
Accessions	EAW90502 EAW90503 EAW90504 EAW90505 Q8NET8 AF514998 AAM54027 AJ487035 CAD31711 AK074032 BAB84858 AK092557 AK127330 BAG54484 AK127726 BAG54559 AK304768 BAG65523 AY118267 AAM80558 AY118268 AAM80559 BC104866 AAI04867 BC104868 AAI04869 BC143294 AAI43295 BC143295 BC143299 AAI43300 BC143330 AAI43331 BC143333 BC143334 BC143336 BX537539 EU295940 ACA81614 XM_011523693 XP_011521995 XM_011523694 XP_011521996 XM_011523695 XP_011521997 XR_934004 NM_001258205 NP_001245134 NM_145068 NP_659505
Function	Putative receptor-activated non-selective calcium permeant cation channel. It is activated by innocuous (warm) temperatures and shows an increased response at noxious temperatures greater than 39 degrees Celsius. Activation exhibits an outward rectification. May associate with TRPV1 and may modulate its activity. Is a negative regulator of hair growth and cycling: TRPV3-coupled signaling suppresses keratinocyte proliferation in hair follicles and induces apoptosis and premature hair follicle regression (catagen). {ECO:0000269|PubMed:12077604, ECO:0000269|PubMed:12077606, ECO:0000269|PubMed:21593771}.
Subcellular Location	Membrane; Multi-pass membrane protein.
Tissue Specificity	Abundantly expressed in CNS. Widely expressed at low levels. Detected in dorsal root ganglion (at protein level). Expressed in the keratinocyte layers of the outer root sheath and, to lesser extent, to the matrix of the hair follicles (at protein level). {ECO:0000269|PubMed:12077604, ECO:0000269|PubMed:12077606, ECO:0000269|PubMed:21593771}.
Top Pathways	Inflammatory mediator regulation of TRP channels

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human TRPV3 peptide - ab32733 from Abcam Category Peptide

Human TRPV3 protein fragment - ab112434 from Abcam Category Protein Source Wheat germ Species Human

TRPV3 peptide - ab48072 from Abcam Category Peptide

TRPV3 Antibody Blocking Peptide - LS-E3121 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TRPV3 Antibody Blocking Peptide - LS-E26816 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Vanilloid R-like 3/TRPV3 Protein - H00162514-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Rat-TRPV3-Antibody-C-term-Blocking-Peptide - BP1425b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg Species Rat

TRPV3 (aa607-618) blocking peptide - GTX89346-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Dog

TRPV3 (aa610-622) blocking peptide - GTX88785-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human

TRPV3 (aa762-773) blocking peptide - GTX88648-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Rat

TRPV3 Blocking Peptide - abx064077 from Abbexa Category Peptide Species Human

TRPV3 Peptide - AC21-1648-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

TRPV3 / Vanilloid receptor-like 3 - H00162514-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

TRPV3 / Vanilloid receptor-like 3 - H00162514-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

TRPV3 Peptide - 46-915P from ProSci Category Peptide Species Human

Recombinant Human TRPV3 - TRPV3-28682TH from Creative Biomart Category Protein Source Wheat germ

Recombinant Transient Receptor Potential Cation Channel Subfamily V, Member 3 (TRPV3) - RPF848Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

TRPV3 Blocking Peptide - CBP2883 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human

Recombinant Transient Receptor Potential Cation Channel Subfamily V, Member 3 (TRPV3) - RPF848Hu01 from Cloud-clone Category Protein Source E.coli Species Human

TRPV3, Peptide - MBS425691 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human, Mouse, Rat, Dog

TRPV3 Peptide, Human - M34GP16691H from Creative Peptides Category Peptide Source Synthetic. Species Human

TRPV3 Recombinant Protein (OPCD07725) - OPCD07725 from Aviva Systems Biology Category Protein Source E.coli Species Human

Vanilloid R-like 3/TRPV3 Recombinant Protein Antigen - NBP2-57314PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

TRPV3 peptide - orb218746 from Biorbyt Category Peptide Species Human

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