TRPV3

Gene Symbol TRPV3
Entrez Gene 162514
Alt Symbol OLMS, VRL3
Species Human
Gene Type protein-coding
Description transient receptor potential cation channel, subfamily V, member 3
Other Description VRL-3|transient receptor potential cation channel subfamily V member 3|vanilloid receptor-like 3|vanilloid receptor-related osmotically activated channel protein
Swissprots Q8NFH2 Q8NDW7 Q8NET9 Q8NET8
Accessions EAW90502 EAW90503 EAW90504 EAW90505 Q8NET8 AF514998 AAM54027 AJ487035 CAD31711 AK074032 BAB84858 AK092557 AK127330 BAG54484 AK127726 BAG54559 AK304768 BAG65523 AY118267 AAM80558 AY118268 AAM80559 BC104866 AAI04867 BC104868 AAI04869 BC143294 AAI43295 BC143295 BC143299 AAI43300 BC143330 AAI43331 BC143333 BC143334 BC143336 BX537539 EU295940 ACA81614 XM_011523693 XP_011521995 XM_011523694 XP_011521996 XM_011523695 XP_011521997 XR_934004 NM_001258205 NP_001245134 NM_145068 NP_659505
Function Putative receptor-activated non-selective calcium permeant cation channel. It is activated by innocuous (warm) temperatures and shows an increased response at noxious temperatures greater than 39 degrees Celsius. Activation exhibits an outward rectification. May associate with TRPV1 and may modulate its activity. Is a negative regulator of hair growth and cycling: TRPV3-coupled signaling suppresses keratinocyte proliferation in hair follicles and induces apoptosis and premature hair follicle regression (catagen). {ECO:0000269|PubMed:12077604, ECO:0000269|PubMed:12077606, ECO:0000269|PubMed:21593771}.
Subcellular Location Membrane; Multi-pass membrane protein.
Tissue Specificity Abundantly expressed in CNS. Widely expressed at low levels. Detected in dorsal root ganglion (at protein level). Expressed in the keratinocyte layers of the outer root sheath and, to lesser extent, to the matrix of the hair follicles (at protein level). {ECO:0000269|PubMed:12077604, ECO:0000269|PubMed:12077606, ECO:0000269|PubMed:21593771}.
Top Pathways Inflammatory mediator regulation of TRP channels

TRPV3 CRISPR/Cas9 KO Plasmid (h) - sc-417690 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

TRPV3 HDR Plasmid (h) - sc-417690-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TRPV3 Double Nickase Plasmid (h) - sc-417690-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TRPV3 Double Nickase Plasmid (h2) - sc-417690-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TRPV3 CRISPR Activation Plasmid (h) - sc-417690-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

TRPV3 CRISPR Activation Plasmid (h2) - sc-417690-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

TRPV3 Lentiviral Activation Particles (h) - sc-417690-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TRPV3 Lentiviral Activation Particles (h2) - sc-417690-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TRPV3 siRNA (h) - sc-44170 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

TRPV3 shRNA Plasmid (h) - sc-44170-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

TRPV3 shRNA (h) Lentiviral Particles - sc-44170-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Vanilloid R-like 3/TRPV3 RNAi - H00162514-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU121471 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN22065 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22065 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR05864 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr05864

TRPV3 siRNA (Human) - CRJ5952 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

TRPV3 - MBS8208715 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human TRPV3 (NM_145068.3) - SHH435768 from Creative biogene

Category siRNA
Species Reactivities Human

Human TRPV3 siRNA - orb276453 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

TRPV3 shRNA Plasmid (Human) - CHJ5952 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

TRPV3 miRNA 3'UTR clone - MiUTR4H-TG09407 from Creative biogene

Species Reactivities Human
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