| Gene Symbol |
TRPV3
|
| Entrez Gene |
162514
|
| Alt Symbol |
OLMS, VRL3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
transient receptor potential cation channel, subfamily V, member 3
|
| Other Description |
VRL-3|transient receptor potential cation channel subfamily V member 3|vanilloid receptor-like 3|vanilloid receptor-related osmotically activated channel protein
|
| Swissprots |
Q8NFH2 Q8NDW7 Q8NET9 Q8NET8
|
| Accessions |
EAW90502 EAW90503 EAW90504 EAW90505 Q8NET8 AF514998 AAM54027 AJ487035 CAD31711 AK074032 BAB84858 AK092557 AK127330 BAG54484 AK127726 BAG54559 AK304768 BAG65523 AY118267 AAM80558 AY118268 AAM80559 BC104866 AAI04867 BC104868 AAI04869 BC143294 AAI43295 BC143295 BC143299 AAI43300 BC143330 AAI43331 BC143333 BC143334 BC143336 BX537539 EU295940 ACA81614 XM_011523693 XP_011521995 XM_011523694 XP_011521996 XM_011523695 XP_011521997 XR_934004 NM_001258205 NP_001245134 NM_145068 NP_659505
|
| Function |
Putative receptor-activated non-selective calcium permeant cation channel. It is activated by innocuous (warm) temperatures and shows an increased response at noxious temperatures greater than 39 degrees Celsius. Activation exhibits an outward rectification. May associate with TRPV1 and may modulate its activity. Is a negative regulator of hair growth and cycling: TRPV3-coupled signaling suppresses keratinocyte proliferation in hair follicles and induces apoptosis and premature hair follicle regression (catagen). {ECO:0000269|PubMed:12077604, ECO:0000269|PubMed:12077606, ECO:0000269|PubMed:21593771}.
|
| Subcellular Location |
Membrane; Multi-pass membrane protein.
|
| Tissue Specificity |
Abundantly expressed in CNS. Widely expressed at low levels. Detected in dorsal root ganglion (at protein level). Expressed in the keratinocyte layers of the outer root sheath and, to lesser extent, to the matrix of the hair follicles (at protein level). {ECO:0000269|PubMed:12077604, ECO:0000269|PubMed:12077606, ECO:0000269|PubMed:21593771}.
|
| Top Pathways |
Inflammatory mediator regulation of TRP channels
|