STK4

Gene Symbol	STK4
Entrez Gene	6789
Alt Symbol	KRS2, MST1, TIIAC, YSK3
Species	Human
Gene Type	protein-coding
Description	serine/threonine kinase 4
Other Description	MST-1|STE20-like kinase MST1|dJ211D12.2 (serine/threonine kinase 4 (MST1, KRS2))|kinase responsive to stress 2|mammalian STE20-like protein kinase 1|mammalian sterile 20-like 1|serine/threonine-protein kinase 4|serine/threonine-protein kinase Krs-2
Swissprots	Q5H982 Q15802 B2RCR8 Q9BR32 Q13043 Q4G156 Q9NTZ4 Q6PD60
Accessions	EAW75882 EAW75883 Q13043 AB209315 BAD92552 AK027088 AK225326 AK309169 AK315238 BAG37665 AL597960 BC005231 AAH05231 BC015332 AAH15332 BC029511 AAH29511 BC038850 BC039023 BC042861 BC058916 AAH58916 BC065215 BC093768 AAH93768 BM450795 BM455776 BM459914 BQ216721 BQ434275 BU153393 BU429479 BU633556 BU689980 BU902081 CR933633 CAI45939 T18610 U18297 AAA83254 U60207 AAB17262 Z25430 CAA80917 XM_005260530 XP_005260587 XM_005260531 XP_005260588 XM_005260532 XP_005260589 XM_005260533 XP_005260590 XM_011529017 XP_011527319 XM_011529018 XP_011527320 XM_011529019 XP_011527321 XM_011529020 XP_011527322 NM_006282 NP_006273
Function	Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation
Subcellular Location	Cytoplasm. Nucleus. Note=The caspase-cleaved form cycles between the nucleus and cytoplasm.
Tissue Specificity	Expressed in prostate cancer and levels increase from the normal to the malignant state (at protein level). Ubiquitously expressed. {ECO:0000269|PubMed:17932490}.
Top Pathways	Non-small cell lung cancer, MAPK signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Mouse/Human Phospho-STK3 (Thr183) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1262 from LifeSpan Bioscience Category ELISA Kit Prices $550.00 Sizes 1 plate

Mouse MST1 ELISA Kit (Sandwich ELISA) - LS-F2872 from LifeSpan Bioscience Category ELISA Kit Prices $530.00 Sizes 1 plate Sensitivity 156 pg/ml Range 2.743-666.7 pg/ml

Human MST1 ELISA Kit - abx056286 from Abbexa Category ELISA Kit

Hepatocyte growth factor-like protein, MST1, Human, ELISA Kit - E1121h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t

Macrophage Stimulating Protein (MSP), Human, ELISA Kit - SEB121Hu from ARP American Research Products Category ELISA Kit Prices $685.00 Sizes 96 t Sensitivity 0.112ng/mL Range 0.312-20ng/mL

Serine/threonine-protein kinase 4 (STK4), Human, ELISA Kit - E01S0411 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t

MST1, ELISA Kit - MBS824743 from MyBioSource Category ELISA Kit Prices $470.00 Sizes 96 tests Sensitivity 10 pg/ml Range 156 pg/ml - 10000 pg/ml

Mst1/2 (Phospho-Thr183) Colorimetric Cell-Based ELISA Kit - CBP1262 from Assay Biotechnology Category ELISA Kit Prices $480.00, $960.00, $1,440.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

MST1 (Human) ELISA Kit - DEIA3957 from Creative Diagnostics Category ELISA Kit Sensitivity The minimum detectable dose of MST1 is typically less than 8 pg/mL.

serine/threonine kinase 4, ELISA Kit - MBS9329504 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Serine/threonine protein kinase 4 (STK4), ELISA Kit - MBS7224569 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Human STK4 / MST1 ELISA Pair Set - SEK11533-5 from Sino Biological Category ELISA Kit Prices $350.00, $350.00 Sizes 5 plates, 15 plates

Human MST1 ELISA Kit - CEK1286 from Cohesion Biosciences Category ELISA Kit Prices $360.00 Sizes 96 t Sensitivity 10 pg/ml Range 156 pg/ml - 10000 pg/ml

ELISA Kit for Macrophage Stimulating Protein (MSP) - SEB121Hu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.051ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA's were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

Human MST1 ELISA Kit (Sandwich ELISA) - LS-F24628 from LifeSpan Bioscience Category ELISA Kit Prices $550.00 Sizes 1 plate Sensitivity 10 pg/ml Range 2.743-666.7 pg/ml

Mouse MST1 ELISA Kit (Sandwich ELISA) - LS-F24874 from LifeSpan Bioscience Category ELISA Kit Prices $550.00 Sizes 1 plate Sensitivity 10 pg/ml Range 2.743-666.7 pg/ml

Mst1/2 ELISA Kit - DEIA-XYA1236 from Creative Diagnostics Category ELISA Kit

Mst1/2 (Phospho-Thr183) ELISA Kit - DEIA-XYA1237 from Creative Diagnostics Category ELISA Kit

Human STK4 ELISA Pair Set - orb146002 from Biorbyt Category ELISA Kit Prices $510.00, $1,148.00 Sizes 5 plates, 15 plates

Human STK4 / MST1 ELISA Kit - NS-E10134 from Novatein Biosciences Category ELISA Kit Prices $459.00 Sizes 96 t Sensitivity 70 pg/ml Range 78.125 - 5000 pg/ml

Human MST1 ELISA Kit - E024985 from Biobool Category ELISA Kit Sensitivity < 10pg/ml

Human STK4 ELISA Kit - E024987 from Biobool Category ELISA Kit Sensitivity 10 pg/ml

Mst1/2 Colorimetric Cell-Based ELISA Kit - EKA50407 from Biomatik Category ELISA Kit Prices $399.00 Sizes 96 tests Sensitivity At least 5000 cells/well Range Qualitative

Phospho-Mst1/2 (Thr183) Colorimetric Cell-Based ELISA Kit - EKA51200 from Biomatik Category ELISA Kit Prices $504.00 Sizes 192 tests Sensitivity At least 5000 cells/well Range Qualitative

Search more