STK4

Gene Symbol	STK4
Entrez Gene	6789
Alt Symbol	KRS2, MST1, TIIAC, YSK3
Species	Human
Gene Type	protein-coding
Description	serine/threonine kinase 4
Other Description	MST-1|STE20-like kinase MST1|dJ211D12.2 (serine/threonine kinase 4 (MST1, KRS2))|kinase responsive to stress 2|mammalian STE20-like protein kinase 1|mammalian sterile 20-like 1|serine/threonine-protein kinase 4|serine/threonine-protein kinase Krs-2
Swissprots	Q5H982 Q15802 B2RCR8 Q9BR32 Q13043 Q4G156 Q9NTZ4 Q6PD60
Accessions	EAW75882 EAW75883 Q13043 AB209315 BAD92552 AK027088 AK225326 AK309169 AK315238 BAG37665 AL597960 BC005231 AAH05231 BC015332 AAH15332 BC029511 AAH29511 BC038850 BC039023 BC042861 BC058916 AAH58916 BC065215 BC093768 AAH93768 BM450795 BM455776 BM459914 BQ216721 BQ434275 BU153393 BU429479 BU633556 BU689980 BU902081 CR933633 CAI45939 T18610 U18297 AAA83254 U60207 AAB17262 Z25430 CAA80917 XM_005260530 XP_005260587 XM_005260531 XP_005260588 XM_005260532 XP_005260589 XM_005260533 XP_005260590 XM_011529017 XP_011527319 XM_011529018 XP_011527320 XM_011529019 XP_011527321 XM_011529020 XP_011527322 NM_006282 NP_006273
Function	Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation
Subcellular Location	Cytoplasm. Nucleus. Note=The caspase-cleaved form cycles between the nucleus and cytoplasm.
Tissue Specificity	Expressed in prostate cancer and levels increase from the normal to the malignant state (at protein level). Ubiquitously expressed. {ECO:0000269|PubMed:17932490}.
Top Pathways	Non-small cell lung cancer, MAPK signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Krs-2 CRISPR/Cas9 KO Plasmid (h) - sc-403632 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Krs-2 HDR Plasmid (h) - sc-403632-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Krs-2 Double Nickase Plasmid (h) - sc-403632-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Krs-2 Double Nickase Plasmid (h2) - sc-403632-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Krs-2 CRISPR Activation Plasmid (h) - sc-403632-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Krs-2 CRISPR Activation Plasmid (h2) - sc-403632-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Krs-2 Lentiviral Activation Particles (h) - sc-403632-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Krs-2 Lentiviral Activation Particles (h2) - sc-403632-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Krs-2 siRNA (h) - sc-39249 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Krs-2 shRNA Plasmid (h) - sc-39249-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Krs-2 shRNA (h) Lentiviral Particles - sc-39249-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

MSP/MST1 RNAi - H00004485-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

STK4 RNAi - H00006789-R03 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU012211 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

MISSION® siRNA - SIHK2199 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK2200 from Sigma-Aldrich Category siRNA

MISSION® siRNA - SIHK2198 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

CompoZr® Knockout ZFN Kit - CKOZFN2338 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2338 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

STK4 siRNA (Human) - CRH4645 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

STK4 - MBS8230567 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human STK4 (NM_006282.2) - SHH419908 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human STK4(NM_006282.2) - SHH222396 from Creative biogene Category siRNA Species Reactivities Human

Human STK4 siRNA - orb265147 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

STK4 shRNA Plasmid (Human) - CHH4645 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

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