STK4

Gene Symbol	STK4
Entrez Gene	6789
Alt Symbol	KRS2, MST1, TIIAC, YSK3
Species	Human
Gene Type	protein-coding
Description	serine/threonine kinase 4
Other Description	MST-1|STE20-like kinase MST1|dJ211D12.2 (serine/threonine kinase 4 (MST1, KRS2))|kinase responsive to stress 2|mammalian STE20-like protein kinase 1|mammalian sterile 20-like 1|serine/threonine-protein kinase 4|serine/threonine-protein kinase Krs-2
Swissprots	Q5H982 Q15802 B2RCR8 Q9BR32 Q13043 Q4G156 Q9NTZ4 Q6PD60
Accessions	EAW75882 EAW75883 Q13043 AB209315 BAD92552 AK027088 AK225326 AK309169 AK315238 BAG37665 AL597960 BC005231 AAH05231 BC015332 AAH15332 BC029511 AAH29511 BC038850 BC039023 BC042861 BC058916 AAH58916 BC065215 BC093768 AAH93768 BM450795 BM455776 BM459914 BQ216721 BQ434275 BU153393 BU429479 BU633556 BU689980 BU902081 CR933633 CAI45939 T18610 U18297 AAA83254 U60207 AAB17262 Z25430 CAA80917 XM_005260530 XP_005260587 XM_005260531 XP_005260588 XM_005260532 XP_005260589 XM_005260533 XP_005260590 XM_011529017 XP_011527319 XM_011529018 XP_011527320 XM_011529019 XP_011527321 XM_011529020 XP_011527322 NM_006282 NP_006273
Function	Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation
Subcellular Location	Cytoplasm. Nucleus. Note=The caspase-cleaved form cycles between the nucleus and cytoplasm.
Tissue Specificity	Expressed in prostate cancer and levels increase from the normal to the malignant state (at protein level). Ubiquitously expressed. {ECO:0000269|PubMed:17932490}.
Top Pathways	Non-small cell lung cancer, MAPK signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

STK4-Over-expression-Lysate - LY10264a from Abgent, a WuXi AppTec company Category Cell Lysate Prices $325.00 Sizes 100 µg

STK4 293 Cell Lysate - 401686 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

STK4 Overexpression Lysate (Native) - NBL1-16555 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

STK4 Over-expression Lysate Product - GWB-27199D from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

Human STK4 / MST1 Insect Cell Lysate (WB positive control) - 11533-H07BL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

Human MST-1 Baculovirus-Insect Cells Transfected Lysate (positive control) (denatured) - orb175026 from Biorbyt Category Cell Lysate Prices $604.00 Sizes 300 μg Species Human

Panoply™ Human STK4 Knockdown Stable Cell Line - CSC-DC015322 from Creative biogene Category Cell Line Species Human

STK4 Knockout Cell Line-HeLa - CSC-RT1849 from Creative biogene Category Cell Line Species Human

STK4 KO Cell Lysate-HeLa - CLKO-1698 from Creative biogene Category Cell Lysate

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