STK4

Gene Symbol STK4
Entrez Gene 6789
Alt Symbol KRS2, MST1, TIIAC, YSK3
Species Human
Gene Type protein-coding
Description serine/threonine kinase 4
Other Description MST-1|STE20-like kinase MST1|dJ211D12.2 (serine/threonine kinase 4 (MST1, KRS2))|kinase responsive to stress 2|mammalian STE20-like protein kinase 1|mammalian sterile 20-like 1|serine/threonine-protein kinase 4|serine/threonine-protein kinase Krs-2
Swissprots Q5H982 Q15802 B2RCR8 Q9BR32 Q13043 Q4G156 Q9NTZ4 Q6PD60
Accessions EAW75882 EAW75883 Q13043 AB209315 BAD92552 AK027088 AK225326 AK309169 AK315238 BAG37665 AL597960 BC005231 AAH05231 BC015332 AAH15332 BC029511 AAH29511 BC038850 BC039023 BC042861 BC058916 AAH58916 BC065215 BC093768 AAH93768 BM450795 BM455776 BM459914 BQ216721 BQ434275 BU153393 BU429479 BU633556 BU689980 BU902081 CR933633 CAI45939 T18610 U18297 AAA83254 U60207 AAB17262 Z25430 CAA80917 XM_005260530 XP_005260587 XM_005260531 XP_005260588 XM_005260532 XP_005260589 XM_005260533 XP_005260590 XM_011529017 XP_011527319 XM_011529018 XP_011527320 XM_011529019 XP_011527321 XM_011529020 XP_011527322 NM_006282 NP_006273
Function Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation
Subcellular Location Cytoplasm. Nucleus. Note=The caspase-cleaved form cycles between the nucleus and cytoplasm.
Tissue Specificity Expressed in prostate cancer and levels increase from the normal to the malignant state (at protein level). Ubiquitously expressed. {ECO:0000269|PubMed:17932490}.
Top Pathways Non-small cell lung cancer, MAPK signaling pathway

Phospho-MST1 (Thr183)/MST2 (Thr180) Antibody - 3681 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from WEHI-231 cells and guinea pig neutrophils treated with Staurosporine #9953 for the indicated times, using Phospho-MST1 (Thr183)/MST2 (Thr180) Antibody (upper) and MST1 Antibody #3682 (lower).

MST1 Antibody - 3682 from Cell Signaling Technology

Prices $99.00, $246.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from various cell lines using MST1 Antibody.

MST1 (D8B9Q) Rabbit mAb - 14946 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D8B9Q
Western blot analysis of extracts from various cell lines using MST1 (D8B9Q) Rabbit mAb.

Krs-2 (N-19) - sc-6213 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Krs-2 (N-19): sc-6213. Immunoperoxidase staining of formalin fixed, paraffin-embedded human lymph node tissue showing cytoplasmic staining of cells in germinal and non-germinal centers.

Krs-2 (RJ-5) - sc-100449 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
Krs-2 (RJ-5): sc-100449. Western blot analysis of Krs-2 expression in HeLa nuclear extract.

Krs-2 (E-21) - sc-130797 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
Krs-2 (E-21): sc-130797. Western blot analysis of Krs-2 expression in Jurkat whole cell lysate.

Anti-Serine/threonine-protein kinase 4 (phospho T183) antibody - ab63474 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry analysis of paraffin-embedded human brain tissue using Serine/threonine-protein kinase 4 (phospho T183) antibody (ab63474) at 1/50 dilution, in the presence (right panel) or absence (left panel) of the immunising phosphopeptide.

Anti-Serine/threonine-protein kinase 4 antibody - ab57836 from Abcam

Prices $385.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Serine/threonine-protein kinase 4antibody (ab57836) used in immunofluorescence at 10ug/ml on HeLa cells.

Anti-Serine/threonine-protein kinase 4 antibody - ab59298 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Ab59298 at 1/50 dilution staining human brain tissue without (left) and with (right) immunizing peptide; paraffin embedded.

Anti-Serine/threonine-protein kinase 4 antibody - ab57837 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-Serine/threonine-protein kinase 4 antibody - ab25136 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-Serine/threonine-protein kinase 4 antibody - ab184636 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunocytochemical analysis of HepG2 cells fixed in 4% paraformaldehyde for 15 mins at room temperature labeling Serine/threonine-protein kinase 4 with ab184636 at 1/500 dilution (green) and counterstained with Hoechst 33342 (blue)

Anti-Serine/threonine-protein kinase 4 antibody - ab13865 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-Serine/threonine-protein kinase 4 antibody [EP1465Y] - ab51134 from Abcam

Prices $381.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP1465Y
Anti-Serine/threonine-protein kinase 4 antibody [EP1465Y] (ab51134) at 1/10000 dilution + HeLa cell lysate at 10 µgSecondaryGoat anti-rabbit HRP labeled at 1/2000 dilution

Anti-SKT3 / STK4 Antibody (aa131-180) - LS-C199915 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of extracts from 293 cells, using Krs-1/2 antibody.

Anti-STK4 Antibody (clone 1D7-8A10) - LS-C133457 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1D7-8A10
Immunoperoxidase of monoclonal antibody to STK4 on formalin-fixed paraffin-embedded human stomach carcinoma tissue. [antibody concentration 5 ug/ml].

Anti-STK4 Antibody (aa276-487) - LS-C16613 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-STK4 Antibody (N-Terminus) - LS-C16615 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-MST1 + MST2 Antibody (phospho-Thr183/Thr180) - LS-C25667 from LifeSpan Bioscience

Prices $425.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-STK4 Antibody (phospho-Thr183, clone EPR1467Y) - LS-C50061 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR1467Y
Western blot analysis on HeLa cell lysates using anti-Phospho-Mst1 (pT183)/ Mst2 (pT180) antibody, 1:2000 dilution (A, B); Mst1 (1941-1), 1:5000 dilution (C, D) Cells were either (A, C) untreated or (B, D) treated with Calyculin A.

Anti-STK4 Antibody (aa372-390) - LS-C705 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of MST-1 in 15 ugs of Jurkat cell lysate using antibody at 1 ug/ml.

Anti-STK4 Antibody (aa13) - LS-C190253 from LifeSpan Bioscience

Prices $425.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-STK4 Antibody (aa393-422, AP) - LS-C223352 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-STK4 Antibody (aa393-422, APC) - LS-C223353 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-STK4 Antibody (aa393-422, Biotin) - LS-C223354 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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