| Gene Symbol |
CHPF
|
| Entrez Gene |
79586
|
| Alt Symbol |
CHSY2, CSS2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
chondroitin polymerizing factor
|
| Other Description |
N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase II|N-acetylgalactosaminyltransferase 2|chondroitin glucuronyltransferase 2|chondroitin sulfate synthase 2|chondroitin-polymerizing factor|glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase II
|
| Swissprots |
Q9H0F8 Q7L4G1 Q8IZ52 Q9H618 Q6UXD6 B4DXU0
|
| Accessions |
EAW70764 EAW70765 EAW70766 EAW70767 EAW70768 EAW70769 EAW70770 Q8IZ52 AB086063 BAC81536 AB095813 BAC78393 AK026331 BAB15449 AK302124 BAG63502 AL136814 CAB66748 AY358403 AAQ88769 BC008878 AAH08878 BC021223 AAH21223 BC023531 AAH23531 DC341343 XM_011511838 XP_011510140 NM_001195731 NP_001182660 NM_024536 NP_078812
|
| Function |
Has both beta-1,3-glucuronic acid and beta-1,4-N- acetylgalactosamine transferase activity. Transfers glucuronic acid (GlcUA) from UDP-GlcUA and N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of the elongating chondroitin polymer. Isoform 2 may facilitate PARK2 transport into the mitochondria. In collaboration with PARK2, isoform 2 may enhance cell viability and protect cells from oxidative stress. {ECO:0000269|PubMed:12761225}.
|
| Subcellular Location |
Isoform 2: Mitochondrion matrix {ECO:0000305}.
|
| Tissue Specificity |
Ubiquitous. Highly expressed in pancreas, ovary, brain, heart, skeletal muscle, colon, kidney, liver, stomach, spleen and placenta. Isoform 3 is also ubiquitous. Isoform 2 is expressed in brain, spleen, ovary, testis, lung and peripheral mononuclear cells. {ECO:0000269|PubMed:12716890, ECO:0000269|PubMed:12761225, ECO:0000269|PubMed:22082830}.
|
| Top Pathways |
Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate
|