Gene Symbol | BLOC1S1 |
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Entrez Gene | 2647 |
Alt Symbol | BLOS1, GCN5L1, MICoA, RT14 |
Species | Human |
Gene Type | protein-coding |
Description | biogenesis of lysosomal organelles complex-1, subunit 1 |
Other Description | BLOC subunit 1|BLOC-1 subunit 1|GCN5 (general control of amino-acid synthesis, yeast, homolog)-like 1|GCN5 general control of amino-acid synthesis 5-like 1|GCN5-like protein 1|MTA1-interacting coactivator|biogenesis of lysosome-related organelles complex 1 subunit 1 |
Swissprots | P78537 Q6NZ45 A1L4Q9 |
Accessions | EAW96824 P78537 AI673441 AI816035 AK307069 BC066340 BC130640 AAI30641 BC132795 AAI32796 BQ899204 BU601406 CN263524 D64007 BAA10887 DA243440 DA864590 S82447 AAB37682 NR_037656 NR_037657 NM_001487 NP_001478 NR_037655 |
Function | Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May negatively regulate aerobic respiration through mitochondrial protein lysine-acetylation. May counteract the action of the deacetylase SIRT3 by acetylating and regulating proteins of the mitochondrial respiratory chain including ATP5A1 and NDUFA9. {ECO:0000269|PubMed:17182842, ECO:0000269|PubMed:22309213}. |
Subcellular Location | Mitochondrion intermembrane space {ECO:0000269|PubMed:22309213}. Mitochondrion matrix {ECO:0000269|PubMed:22309213}. Cytoplasm, cytosol {ECO:0000269|PubMed:22309213}. |
BLOS1 (C-18) - sc-167208 from Santa Cruz Biotechnology
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Anti-BLOC1S1 antibody - ab121669 from Abcam
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Anti-BLOC1S1 Antibody (aa22-71) - LS-C186668 from LifeSpan Bioscience
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Anti-BLOC1S1 Antibody - LS-C211666 from LifeSpan Bioscience
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Anti-BLOC1S1 Antibody (HRP) - LS-C211667 from LifeSpan Bioscience
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Anti-BLOC1S1 Antibody (FITC) - LS-C211669 from LifeSpan Bioscience
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Anti-BLOC1S1 Antibody (Biotin) - LS-C211670 from LifeSpan Bioscience
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BLOC1S1 Antibody - NBP1-88583 from Novus Biologicals
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Anti-BLOC1S1 antibody produced in rabbit - HPA021381 from Sigma-Aldrich
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BLOC1S1 Antibody - N-terminal region (ARP38042_P050) - ARP38042_P050 from Aviva Systems Biology
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BLOC1S1 antibody - 70R-21463 from Fitzgerald
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BLOC1 antibody - 70R-15337 from Fitzgerald
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Biogenesis of lysosome-related organelles complex 1 subunit 1 antibody (Biotin) - orb240224 from Biorbyt
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BLOC1 antibody (biotin) - 60R-1840 from Fitzgerald
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BLOC1 antibody (HRP) - 60R-1838 from Fitzgerald
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BLOC1 antibody (FITC) - 60R-1839 from Fitzgerald
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BLOC1S1 Antibody - abx111228 from Abbexa
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BLOC1S1 Antibody (Biotin) - abx105192 from Abbexa
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BLOC1S1 Antibody (HRP) - abx108026 from Abbexa
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BLOS1 Antibody - abx109579 from Abbexa
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BLOS1 Antibody (FITC) - abx106609 from Abbexa
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BLOC-1 subunit 1 antibody - 19687-1-AP from Acris Antibodies
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Anti-Biogenesis of lysosome-related organelles complex 1 subunit 1 - 15-1077-1 from ARP American Research Products
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Anti-Biogenesis of lysosome-related organelles complex 1 subunit 1, Biotin - 15-1077-2 from ARP American Research Products
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Anti-Biogenesis of lysosome-related organelles complex 1 subunit 1, FITC - 15-1077-3 from ARP American Research Products
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