BLOC1S1

Gene Symbol BLOC1S1
Entrez Gene 2647
Alt Symbol BLOS1, GCN5L1, MICoA, RT14
Species Human
Gene Type protein-coding
Description biogenesis of lysosomal organelles complex-1, subunit 1
Other Description BLOC subunit 1|BLOC-1 subunit 1|GCN5 (general control of amino-acid synthesis, yeast, homolog)-like 1|GCN5 general control of amino-acid synthesis 5-like 1|GCN5-like protein 1|MTA1-interacting coactivator|biogenesis of lysosome-related organelles complex 1 subunit 1
Swissprots P78537 Q6NZ45 A1L4Q9
Accessions EAW96824 P78537 AI673441 AI816035 AK307069 BC066340 BC130640 AAI30641 BC132795 AAI32796 BQ899204 BU601406 CN263524 D64007 BAA10887 DA243440 DA864590 S82447 AAB37682 NR_037656 NR_037657 NM_001487 NP_001478 NR_037655
Function Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May negatively regulate aerobic respiration through mitochondrial protein lysine-acetylation. May counteract the action of the deacetylase SIRT3 by acetylating and regulating proteins of the mitochondrial respiratory chain including ATP5A1 and NDUFA9. {ECO:0000269|PubMed:17182842, ECO:0000269|PubMed:22309213}.
Subcellular Location Mitochondrion intermembrane space {ECO:0000269|PubMed:22309213}. Mitochondrion matrix {ECO:0000269|PubMed:22309213}. Cytoplasm, cytosol {ECO:0000269|PubMed:22309213}.

BLOS1 CRISPR/Cas9 KO Plasmid (h) - sc-406825 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

BLOS1 HDR Plasmid (h) - sc-406825-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

BLOS1 Double Nickase Plasmid (h) - sc-406825-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

BLOS1 Double Nickase Plasmid (h2) - sc-406825-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

BLOS1 CRISPR Activation Plasmid (h) - sc-406825-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

BLOS1 CRISPR Activation Plasmid (h2) - sc-406825-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

BLOS1 Lentiviral Activation Particles (h) - sc-406825-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

BLOS1 Lentiviral Activation Particles (h2) - sc-406825-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

BLOS1 siRNA (h) - sc-96033 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

BLOS1 shRNA Plasmid (h) - sc-96033-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

BLOS1 shRNA (h) Lentiviral Particles - sc-96033-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU040711 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN3989 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3989 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

BLOC1S1 siRNA (Human) - CRH1761 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

BLOC1S1 - MBS8202977 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human BLOC1S1 (NM_001487.3) - SHH246902 from Creative biogene

Category siRNA
Species Reactivities Human

BLOS1 CRISPR/Cas9 KO Plasmid (h2) - sc-406825-KO-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

BLOS1 HDR Plasmid (h2) - sc-406825-HDR-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Human BLOC1S1 siRNA - orb262263 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

BLOC1S1 shRNA Plasmid (Human) - CHH1761 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

BLOC1S1 miRNA 3'UTR clone - MiUTR3H-04127 from Creative biogene

Species Reactivities Human
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