| Gene Symbol |
NTSR1
|
| Entrez Gene |
4923
|
| Alt Symbol |
NTR
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
neurotensin receptor 1 (high affinity)
|
| Other Description |
NT-R-1|NTR1|NTRH|high-affinity levocabastine-insensitive neurotensin receptor|neurotensin receptor type 1
|
| Swissprots |
Q9H4H1 P30989 Q9H4T5
|
| Accessions |
CAJ34549 EAW75345 P30989 AY429106 AAR07901 BC040711 BC152809 AAI52810 X70070 CAA49675 XM_011528827 XP_011527129 NM_002531 NP_002522
|
| Function |
G-protein coupled receptor for the tridecapeptide neurotensin (NTS). Signaling is effected via G proteins that activate a phosphatidylinositol-calcium second messenger system. Signaling leads to the activation of downstream MAP kinases and protects cells against apoptosis. {ECO:0000269|PubMed:21725197, ECO:0000269|PubMed:23140271, ECO:0000269|PubMed:8381365}.
|
| Subcellular Location |
Cell membrane; Multi-pass membrane protein. Membrane raft. Note=Palmitoylation is required for localization at CAV1-enriched membrane rafts.
|
| Tissue Specificity |
Expressed in prostate (at protein level). Detected in colon and peripheral blood mononuclear cells. Detected at very low levels in brain. {ECO:0000269|PubMed:20048080, ECO:0000269|PubMed:8381365}.
|
| Top Pathways |
Calcium signaling pathway, Neuroactive ligand-receptor interaction
|