Gene Symbol | NTSR1 |
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Entrez Gene | 4923 |
Alt Symbol | NTR |
Species | Human |
Gene Type | protein-coding |
Description | neurotensin receptor 1 (high affinity) |
Other Description | NT-R-1|NTR1|NTRH|high-affinity levocabastine-insensitive neurotensin receptor|neurotensin receptor type 1 |
Swissprots | Q9H4H1 P30989 Q9H4T5 |
Accessions | CAJ34549 EAW75345 P30989 AY429106 AAR07901 BC040711 BC152809 AAI52810 X70070 CAA49675 XM_011528827 XP_011527129 NM_002531 NP_002522 |
Function | G-protein coupled receptor for the tridecapeptide neurotensin (NTS). Signaling is effected via G proteins that activate a phosphatidylinositol-calcium second messenger system. Signaling leads to the activation of downstream MAP kinases and protects cells against apoptosis. {ECO:0000269|PubMed:21725197, ECO:0000269|PubMed:23140271, ECO:0000269|PubMed:8381365}. |
Subcellular Location | Cell membrane; Multi-pass membrane protein. Membrane raft. Note=Palmitoylation is required for localization at CAV1-enriched membrane rafts. |
Tissue Specificity | Expressed in prostate (at protein level). Detected in colon and peripheral blood mononuclear cells. Detected at very low levels in brain. {ECO:0000269|PubMed:20048080, ECO:0000269|PubMed:8381365}. |
Top Pathways | Calcium signaling pathway, Neuroactive ligand-receptor interaction |
NTR1 (C-20) - sc-7596 from Santa Cruz Biotechnology
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NTR1 (H-130) - sc-15311 from Santa Cruz Biotechnology
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NTR1 (G-9) - sc-393205 from Santa Cruz Biotechnology
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NTR1 (B-12) - sc-376958 from Santa Cruz Biotechnology
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NTR1 (N-18) - sc-25042 from Santa Cruz Biotechnology
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Anti-Neurotensin Receptor 1 antibody - ab117592 from Abcam
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Anti-Neurotensin Receptor 1 antibody - ab75555 from Abcam
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Anti-Neurotensin Receptor 1 antibody - ab183088 from Abcam
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Anti-Neurotensin Receptor 1 antibody - ab192680 from Abcam
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Anti-Neurotensin Receptor 1 antibody [B-N6] - ab27380 from Abcam
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Anti-Neurotensin Receptor 1 antibody [B-N6] - ab47176 from Abcam
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Anti-Neurotensin Receptor 1 antibody [B-N6] - ab34353 from Abcam
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Anti-NTSR1 / NTR Antibody (Cytoplasmic Domain) IHC-plus⢠- LS-A938 from LifeSpan Bioscience
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Anti-NTSR1 / NTR Antibody - LS-C25749 from LifeSpan Bioscience
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Anti-NTSR1 / NTR Antibody (C-Terminus) - LS-C25750 from LifeSpan Bioscience
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Anti-NTSR1 / NTR Antibody (C-Terminus) - LS-C25751 from LifeSpan Bioscience
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Anti-NTSR1 / NTR Antibody - LS-C25752 from LifeSpan Bioscience
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Anti-NTSR1 / NTR Antibody - LS-C25753 from LifeSpan Bioscience
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Anti-NTSR1 / NTR Antibody - LS-C341264 from LifeSpan Bioscience
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Anti-NTSR1 / NTR Antibody - LS-C335290 from LifeSpan Bioscience
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Anti-NTSR1 / NTR Antibody (aa35-84) - LS-C107553 from LifeSpan Bioscience
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Anti-NTSR1 / NTR Antibody (C-Terminus) IHC-plus⢠- LS-A939 from LifeSpan Bioscience
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Anti-NTSR1 / NTR Antibody (aa181-230) IHC-plus⢠- LS-B5255 from LifeSpan Bioscience
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Anti-NTSR1 / NTR Antibody (N-Terminus) IHC-plus⢠- LS-A935 from LifeSpan Bioscience
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Neurotensin Receptor 1 Antibody - NBP1-60045 from Novus Biologicals
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