Gene Symbol | NTSR1 |
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Entrez Gene | 4923 |
Alt Symbol | NTR |
Species | Human |
Gene Type | protein-coding |
Description | neurotensin receptor 1 (high affinity) |
Other Description | NT-R-1|NTR1|NTRH|high-affinity levocabastine-insensitive neurotensin receptor|neurotensin receptor type 1 |
Swissprots | Q9H4H1 P30989 Q9H4T5 |
Accessions | CAJ34549 EAW75345 P30989 AY429106 AAR07901 BC040711 BC152809 AAI52810 X70070 CAA49675 XM_011528827 XP_011527129 NM_002531 NP_002522 |
Function | G-protein coupled receptor for the tridecapeptide neurotensin (NTS). Signaling is effected via G proteins that activate a phosphatidylinositol-calcium second messenger system. Signaling leads to the activation of downstream MAP kinases and protects cells against apoptosis. {ECO:0000269|PubMed:21725197, ECO:0000269|PubMed:23140271, ECO:0000269|PubMed:8381365}. |
Subcellular Location | Cell membrane; Multi-pass membrane protein. Membrane raft. Note=Palmitoylation is required for localization at CAV1-enriched membrane rafts. |
Tissue Specificity | Expressed in prostate (at protein level). Detected in colon and peripheral blood mononuclear cells. Detected at very low levels in brain. {ECO:0000269|PubMed:20048080, ECO:0000269|PubMed:8381365}. |
Top Pathways | Calcium signaling pathway, Neuroactive ligand-receptor interaction |
NTSR1 / NTR Antibody Blocking Peptide - LS-E15476 from LifeSpan Bioscience
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NTSR1 / NTR Antibody Blocking Peptide - LS-E29614 from LifeSpan Bioscience
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NTSR1 / NTR Antibody Blocking Peptide - LS-E29622 from LifeSpan Bioscience
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NTSR1 / NTR Antibody Blocking Peptide - LS-E29628 from LifeSpan Bioscience
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Recombinant Human Neurotensin Receptor 1 Protein - H00004923-G01 from Novus Biologicals
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NTSR1 Blocking Peptide - 33R-2909 from Fitzgerald
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Neurotensin receptor 1 - H00004923-G01 from Acris Antibodies
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Recombinant E.coli Thioredoxin Reductase - BP000885-ENZ-507 from Syd Labs
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Recombinant Human NTSR1 - NTSR1-296H from Creative Biomart
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Thioredoxin Reductase (NADPH) Yeast - JNV-314 from Reagent Proteins
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Recombinant Neurotensin Receptor 1, High Affinity (NTSR1) - RPC826Hu01 from Uscn Life Science Inc.
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Recombinant Neurotensin Receptor 1, High Affinity (NTSR1) - RPC826Mu01 from Uscn Life Science Inc.
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Recombinant Neurotensin Receptor 1, High Affinity (NTSR1) - RPC826Mu02 from Uscn Life Science Inc.
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ChemiSCREEN™ NTR1 Membrane Preparation - HTS034M from EMD Millipore
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NTR1 (H218) Peptide - BS2820P from Bioworld Technology
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Recombinant Neurotensin Receptor 1, High Affinity (NTSR1) - RPC826Hu01 from Cloud-clone
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Recombinant TrxR/NTR/Thioredoxin Reductase (NAPH) - CSI12670 from Cell Science
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Recombinant TrxR/NTR/Thioredoxin Reductase (NAPH) - CSI12671 from Cell Science
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Recombinant TrxR/NTR/Thioredoxin Reductase (NAPH) - CSI12672 from Cell Science
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Thioredoxin Reductase (NADPH) Yeast Recombinant - Pr22383 from ProMab
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NTR1 Blocking Peptide - abx061640 from Abbexa
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NTSR1 Peptide, Human - M34GP10686H from Creative Peptides
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NTR1 Blocking Peptide - CBP7030 from Cohesion Biosciences
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Neurotensin receptor type 1 (NTSR1), Recombinant Protein - MBS961323 from MyBioSource
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Neurotensin receptor type 1 (NTSR1), Recombinant Protein - MBS7023676 from MyBioSource
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