| Gene Symbol |
ELL2
|
| Entrez Gene |
22936
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
elongation factor, RNA polymerase II, 2
|
| Other Description |
ELL-related RNA polymerase II, elongation factor|RNA polymerase II elongation factor ELL2
|
| Swissprots |
B4DNK7 O00472
|
| Accessions |
AAC51232 EAW96060 O00472 AB209343 BAD92580 AK296870 BAG59433 AK297956 BAG60269 AK300310 BAG62063 AV652801 BC028412 AAH28412 BC151238 BX538289 CAD98084 DQ891536 ABM82462 DQ894725 ABM85651 XM_006714575 XP_006714638 XM_011543280 XP_011541582 NM_012081 NP_036213
|
| Function |
Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968). Plays a role in immunoglobulin secretion in plasma cells: directs efficient alternative mRNA processing, influencing both proximal poly(A) site choice and exon skipping, as well as immunoglobulin heavy chain (IgH) alternative processing. Probably acts by regulating histone modifications accompanying transition from membrane- specific to secretory IgH mRNA expression. {ECO:0000269|PubMed:20159561, ECO:0000269|PubMed:20471948, ECO:0000269|PubMed:22195968, ECO:0000269|PubMed:23251033}.
|
| Subcellular Location |
Nucleus.
|
![Western Blot: ELL2 Overexpression Lysate (Adult Normal) [NBL1-10237] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for ELL2.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/9726_ELL2%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-10237-img0002.jpg)