| Gene Symbol |
OLAH
|
| Entrez Gene |
55301
|
| Alt Symbol |
AURA1, SAST, THEDC1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
oleoyl-ACP hydrolase
|
| Other Description |
S-acyl fatty acid synthase thioesterase, medium chain|augmented in rheumatoid arthritis 1|thioesterase II|thioesterase domain containing 1|thioesterase domain-containing protein 1
|
| Swissprots |
Q9NUW1 Q5VUB6 Q9NV23
|
| Accessions |
CAE89822 EAW86244 EAW86245 Q9NV23 AK001844 BAA91937 AK001968 BAA92007 BC050372 AAH50372 BG281536 BG722790 BI830605 BR000403 FAA00320 HQ448637 ADQ33115 XM_006717456 XP_006717519 NM_001039702 NP_001034791 NM_018324 NP_060794
|
| Function |
In fatty acid biosynthesis chain termination and release of the free fatty acid product is achieved by hydrolysis of the thio ester by a thioesterase I, a component of the fatty acid synthetase complex. The chain length of the released fatty acid is usually C16. However, in the mammary glands of non-ruminant mammals, and in the uropygial gland of certain waterfowl there exists a second thioesterase which releases medium-chain length fatty acids (C8 to C2) (By similarity). {ECO:0000250}.
|
| Tissue Specificity |
Isoform 2 is up-regulated in bone marrow- derived mononuclear cells of rheumatoid arthritis patients. {ECO:0000269|PubMed:17082220}.
|
| Top Pathways |
Fatty acid biosynthesis
|
![Western Blot: OLAH Overexpression Lysate (Adult Normal) [NBL1-13924] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for OLAH.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/7783_OLAH%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-13924-img0003.jpg)