| Gene Symbol | CHD1 |
|---|---|
| Entrez Gene | 1105 |
| Alt Symbol | - |
| Species | Human |
| Gene Type | protein-coding |
| Description | chromodomain helicase DNA binding protein 1 |
| Other Description | ATP-dependent helicase CHD1|CHD-1|chromodomain-helicase-DNA-binding protein 1 |
| Swissprots | O14646 Q17RZ3 |
| Accessions | CCQ43133 EAW96098 O14646 AF006513 AAB87381 AK094871 BAG52945 BC054860 AAH54860 BC117134 AAI17135 BM698633 BQ436172 BX648767 CN277742 XM_005271866 XP_005271923 XM_005271867 XP_005271924 XM_011543112 XP_011541414 XR_427702 XR_948231 NM_001270 NP_001261 |
| Function | ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. Regulates polymerase II transcription. Also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. Regulates negatively DNA replication. Not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. Is also associated with histone deacetylase (HDAC) activity (By similarity). Required for the bridging of SNF2, the FACT complex, the PAF complex as well as the U2 snRNP complex to H3K4me3. Functions to modulate the efficiency of pre-mRNA splicing in part through physical bridging of spliceosomal components to H3K4me3. Required for maintaining open chromatin and pluripotency in embryonic stem cells. {ECO:0000250, ECO:0000269|PubMed:18042460}. |
| Subcellular Location | Nucleus. Cytoplasm {ECO:0000250}. Note=Is released into the cytoplasm when cells enter mitosis and is reincorporated into chromatin during telophase-cytokinesis. {ECO:0000250}. |