CHD1

Gene Symbol CHD1
Entrez Gene 1105
Alt Symbol -
Species Human
Gene Type protein-coding
Description chromodomain helicase DNA binding protein 1
Other Description ATP-dependent helicase CHD1|CHD-1|chromodomain-helicase-DNA-binding protein 1
Swissprots O14646 Q17RZ3
Accessions CCQ43133 EAW96098 O14646 AF006513 AAB87381 AK094871 BAG52945 BC054860 AAH54860 BC117134 AAI17135 BM698633 BQ436172 BX648767 CN277742 XM_005271866 XP_005271923 XM_005271867 XP_005271924 XM_011543112 XP_011541414 XR_427702 XR_948231 NM_001270 NP_001261
Function ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. Regulates polymerase II transcription. Also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. Regulates negatively DNA replication. Not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. Is also associated with histone deacetylase (HDAC) activity (By similarity). Required for the bridging of SNF2, the FACT complex, the PAF complex as well as the U2 snRNP complex to H3K4me3. Functions to modulate the efficiency of pre-mRNA splicing in part through physical bridging of spliceosomal components to H3K4me3. Required for maintaining open chromatin and pluripotency in embryonic stem cells. {ECO:0000250, ECO:0000269|PubMed:18042460}.
Subcellular Location Nucleus. Cytoplasm {ECO:0000250}. Note=Is released into the cytoplasm when cells enter mitosis and is reincorporated into chromatin during telophase-cytokinesis. {ECO:0000250}.

CHD1 (D8C2) Rabbit mAb - 4351 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D8C2
Western blot analysis of extracts from various cell lines using CHD1 (D8C2) Rabbit mAb.

CHD1 (C-8) - sc-271626 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CHD1 (C-8): sc-271626. Western blot analysis of CHD1 expression in K-562 whole cell lysate.

CHD1 (H-210) - sc-134751 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

CHD1 (N-16) - sc-49813 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
CHD1 (N-16): sc-49813. Immunofluorescence staining of methanol-fixed HeLa cells showing cytoplasmic localization.

CHD1 (C-18) - sc-49810 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-Chd1 antibody - ab94848 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-Chd1 antibody (ab94848) at 1 µg/ml + Human fetal stomach lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-CHD1 Antibody - LS-C332015 from LifeSpan Bioscience

Prices $305.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts of various cell lines, using CHD1 antibody.

Anti-CHD1 Antibody (aa1660-1710) - LS-C288028 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
ChIP-chip scatter plot of anti-CHD1 enriched DNA binding sites versus input reference DNA. A. 10 ug of was used to immunoprecipitate chromatin from K562 cells according to Ren et al (Genes Dev. 2002 16: 245-256). Immunoprecipitated DNA and reference DNA were amplified via ligation-mediated PCR and the products labeled with fluorescent dUTPs. The labeled ChIP and reference DNA were pooled, hybridized to a DNA microarray, and analyzed. Data points below the +3 SD curve (red line) represent significantly enriched binding sites. B. As a control, a similar experiment was performed using normal rabbit IgG. Compared to the anti-CHD1 ChIP, normal rabbit IgG showed little enrichment.

Anti-CHD1 Antibody (clone 1G2) - LS-C196905 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal
Clone 1G2
Immunofluorescence of monoclonal antibody to CHD1 on HeLa cell . [antibody concentration 10 ug/ml]

Anti-CHD1 Antibody (aa68-84) - LS-C3026 from LifeSpan Bioscience

Prices $265.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-CHD1 Antibody (aa1691-1707) - LS-C3027 from LifeSpan Bioscience

Prices $265.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-CHD1 Antibody (aa1500-1550) - LS-C79101 from LifeSpan Bioscience

Prices $545.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-CHD1 Antibody (Internal) - LS-C61720 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-CHD1 Antibody (aa1660-1710) - LS-C79102 from LifeSpan Bioscience

Prices $545.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-CHD1 Antibody (aa1531-1710, clone 11n46) - LS-C184203 from LifeSpan Bioscience

Prices $465.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 11n46

Anti-CHD1 Antibody - LS-C128078 from LifeSpan Bioscience

Prices $605.00
Sizes 100 µg
Host Sheep
Clonality Polyclonal

Anti-CHD1 Antibody (aa1500-1550) - LS-C288029 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-CHD1 Antibody - LS-C347733 from LifeSpan Bioscience

Prices $345.00
Sizes 25 µg
Host Rabbit
Clonality Polyclonal

Anti-CHD1 Antibody (aa1331-1380) - LS-C109901 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
CHD1 antibody LS-C109901 Western blot of Fetal Stomach lysate.

CHD1 Antibody - NB100-60411 from Novus Biologicals

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: CHD1 Antibody [NB100-60411] - Detection of Human CHD1 on HeLa whole cell lysate using NB100-60411. CHD1 was also immunoprecipitated by rabbit anti-CHD1 antibody NB100-60410.

CHD1 Antibody (677616) - MAB6195 from Novus Biologicals

Prices $99.00, $249.00
Sizes 25 µg, 100 µg
Host Mouse
Clonality Monoclonal
Clone 677616

CHD1 Antibody - AF6195 from Novus Biologicals

Prices $99.00, $359.00
Sizes 25 µg, 100 µg
Host Sheep
Clonality Polyclonal
Western blot shows lysates of HepG2 human hepatocellular carcinoma cell line. PVDF Membrane was probed with 1 µg/mL of Sheep Anti-Human/Mouse CHD1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF6195) followed by HRP-conjugated Anti-Sheep IgG Secondary Antibody (Catalog # HAF016). A specific band was detected for CHD1 at approximately 210 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 8.

CHD1 Antibody - NB100-60410 from Novus Biologicals

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: CHD1 Antibody [NB100-60410] - Detection of Human CHD1 on HeLa whole cell lysate using NB100-60410. CHD1 was also immunoprecipitated by rabbit anti-CHD1 antibody NB100-60411.

CHD1 Antibody - NBP2-14478 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry: CHD1 Antibody [NBP2-14478] - Staining of human colon shows strong nuclear and cytoplasmic positivity in glandular cells.

CHD1 Antibody (1G2) - H00001105-M04 from Novus Biologicals

Prices $349.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1G2
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