CHD1

Gene Symbol	CHD1
Entrez Gene	1105
Alt Symbol	-
Species	Human
Gene Type	protein-coding
Description	chromodomain helicase DNA binding protein 1
Other Description	ATP-dependent helicase CHD1|CHD-1|chromodomain-helicase-DNA-binding protein 1
Swissprots	O14646 Q17RZ3
Accessions	CCQ43133 EAW96098 O14646 AF006513 AAB87381 AK094871 BAG52945 BC054860 AAH54860 BC117134 AAI17135 BM698633 BQ436172 BX648767 CN277742 XM_005271866 XP_005271923 XM_005271867 XP_005271924 XM_011543112 XP_011541414 XR_427702 XR_948231 NM_001270 NP_001261
Function	ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. Regulates polymerase II transcription. Also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. Regulates negatively DNA replication. Not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. Is also associated with histone deacetylase (HDAC) activity (By similarity). Required for the bridging of SNF2, the FACT complex, the PAF complex as well as the U2 snRNP complex to H3K4me3. Functions to modulate the efficiency of pre-mRNA splicing in part through physical bridging of spliceosomal components to H3K4me3. Required for maintaining open chromatin and pluripotency in embryonic stem cells. {ECO:0000250, ECO:0000269|PubMed:18042460}.
Subcellular Location	Nucleus. Cytoplasm {ECO:0000250}. Note=Is released into the cytoplasm when cells enter mitosis and is reincorporated into chromatin during telophase-cytokinesis. {ECO:0000250}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SignalSilence ® CHD1 siRNA I - 7168 from Cell Signaling Technology Category siRNA Prices $249.00 Sizes 300 µl (3 nmol)

SignalSilence ® CHD1 siRNA II - 7200 from Cell Signaling Technology Category siRNA Prices $249.00 Sizes 300 µl (3 nmol)

CHD1 CRISPR/Cas9 KO Plasmid (h) - sc-404299 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

CHD1 HDR Plasmid (h) - sc-404299-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

CHD1 Double Nickase Plasmid (h) - sc-404299-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

CHD1 Double Nickase Plasmid (h2) - sc-404299-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

CHD1 CRISPR Activation Plasmid (h) - sc-404299-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

CHD1 CRISPR Activation Plasmid (h2) - sc-404299-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

CHD1 Lentiviral Activation Particles (h) - sc-404299-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

CHD1 Lentiviral Activation Particles (h2) - sc-404299-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

CHD1 siRNA (h) - sc-60363 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

CHD1 shRNA Plasmid (h) - sc-60363-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

CHD1 shRNA (h) Lentiviral Particles - sc-60363-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

MISSION® esiRNA - EHU021261 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN6040 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6040 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR08420 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr08420

CHD1 siRNA (Human) - CRH0787 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

CHD1 RNAi - H00001105-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

CHD1 - MBS8212586 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human CHD1 (NM_001270.2) - SHH262817 from Creative biogene Category siRNA Species Reactivities Human

CHD1 shRNA Plasmid (Human) - CHH0787 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

CHD1 miRNA 3'UTR clone - MiUTR1H-02102 from Creative biogene Species Reactivities Human

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