| Gene Symbol |
DDX60
|
| Entrez Gene |
55601
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
|
| Other Description |
DEAD box protein 60|probable ATP-dependent RNA helicase DDX60
|
| Swissprots |
Q9NVE3 Q6PK35 Q8IY21
|
| Accessions |
CAH61673 EAX04806 EAX04807 EAX04808 EAX04809 Q8IY21 AK000042 BAA90901 AK001649 BAA91809 AK026333 BAB15451 AK223184 BAD96904 AK225191 AK307404 AL137464 CAB70751 BC007820 AAH07820 BC020601 AAH20601 BC038115 AAH38115 BC074781 AAH74781 BX648655 CAE46197 XM_011532103 XP_011530405 XM_011532104 XP_011530406 NM_017631 NP_060101
|
| Function |
Positively regulates DDX58/RIG-I- and IFIH1/MDA5- dependent type I interferon and interferon inducible gene expression in response to viral infection. Binds ssRNA, dsRNA and dsDNA and can promote the binding of DDX58/RIG-I to dsRNA. Exhibits antiviral activity against hepatitis C virus and vesicular stomatitis virus (VSV). {ECO:0000269|PubMed:21478870, ECO:0000269|PubMed:21791617}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:21791617}.
|
| Tissue Specificity |
Brain, lymph node, prostate, stomach, thyroid, tongue, trachea, uterus, skeletal muscle, spleen, kidney, liver and small intestine. {ECO:0000269|PubMed:21791617}.
|
![Western Blot: DDX60 Overexpression Lysate (Adult Normal) [NBP2-06948] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for DDX60.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/8675_DDX60%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-06948-img0001.jpg)