Gene Symbol | DDX60 |
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Entrez Gene | 55601 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 |
Other Description | DEAD box protein 60|probable ATP-dependent RNA helicase DDX60 |
Swissprots | Q9NVE3 Q6PK35 Q8IY21 |
Accessions | CAH61673 EAX04806 EAX04807 EAX04808 EAX04809 Q8IY21 AK000042 BAA90901 AK001649 BAA91809 AK026333 BAB15451 AK223184 BAD96904 AK225191 AK307404 AL137464 CAB70751 BC007820 AAH07820 BC020601 AAH20601 BC038115 AAH38115 BC074781 AAH74781 BX648655 CAE46197 XM_011532103 XP_011530405 XM_011532104 XP_011530406 NM_017631 NP_060101 |
Function | Positively regulates DDX58/RIG-I- and IFIH1/MDA5- dependent type I interferon and interferon inducible gene expression in response to viral infection. Binds ssRNA, dsRNA and dsDNA and can promote the binding of DDX58/RIG-I to dsRNA. Exhibits antiviral activity against hepatitis C virus and vesicular stomatitis virus (VSV). {ECO:0000269|PubMed:21478870, ECO:0000269|PubMed:21791617}. |
Subcellular Location | Cytoplasm {ECO:0000269|PubMed:21791617}. |
Tissue Specificity | Brain, lymph node, prostate, stomach, thyroid, tongue, trachea, uterus, skeletal muscle, spleen, kidney, liver and small intestine. {ECO:0000269|PubMed:21791617}. |
DDX60 CRISPR/Cas9 KO Plasmid (h) - sc-408255 from Santa Cruz Biotechnology
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DDX60 HDR Plasmid (h) - sc-408255-HDR from Santa Cruz Biotechnology
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DDX60 Double Nickase Plasmid (h) - sc-408255-NIC from Santa Cruz Biotechnology
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DDX60 Double Nickase Plasmid (h2) - sc-408255-NIC-2 from Santa Cruz Biotechnology
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DDX60 CRISPR Activation Plasmid (h) - sc-408255-ACT from Santa Cruz Biotechnology
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DDX60 CRISPR Activation Plasmid (h2) - sc-408255-ACT-2 from Santa Cruz Biotechnology
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DDX60 Lentiviral Activation Particles (h) - sc-408255-LAC from Santa Cruz Biotechnology
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DDX60 Lentiviral Activation Particles (h2) - sc-408255-LAC-2 from Santa Cruz Biotechnology
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DDX60 siRNA (h) - sc-89167 from Santa Cruz Biotechnology
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DDX60 shRNA Plasmid (h) - sc-89167-SH from Santa Cruz Biotechnology
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DDX60 shRNA (h) Lentiviral Particles - sc-89167-V from Santa Cruz Biotechnology
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DDX60 RNAi - H00055601-R01 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN7073 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7073 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR05371 from Sigma-Aldrich
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DDX60 siRNA (Human) - CRJ0762 from Cohesion Biosciences
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DDX60 - MBS8208659 from MyBioSource
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shRNA set against Human DDX60 (NM_017631.5) - SHH276209 from Creative biogene
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Human DDX60 siRNA - orb271263 from Biorbyt
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DDX60 shRNA Plasmid (Human) - CHJ0762 from Cohesion Biosciences
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DDX60 miRNA 3'UTR clone - MiUTR3H-13094 from Creative biogene
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