| Gene Symbol |
PTGER1
|
| Entrez Gene |
5731
|
| Alt Symbol |
EP1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
prostaglandin E receptor 1 (subtype EP1), 42kDa
|
| Other Description |
PGE receptor EP1 subtype|PGE receptor, EP1 subtype|PGE2 receptor EP1 subtype|prostaglandin E receptor 1 (subtype EP1), 42kD|prostaglandin E receptor 1, subtype EP1|prostaglandin E2 receptor EP1 subtype|prostanoid EP1 receptor
|
| Swissprots |
Q86VB5 Q5U5U4 Q86UH3 P34995 Q8NHB2
|
| Accessions |
BAC05723 EAW84422 P34995 AY275470 AAP32302 BC029768 AAH29768 BC039034 AAH39034 BC051286 AAH51286 L22647 AAC37539 NM_000955 NP_000946
|
| Function |
Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(q) proteins which activate a phosphatidylinositol-calcium second messenger system. May play a role as an important modulator of renal function. Implicated the smooth muscle contractile response to PGE2 in various tissues.
|
| Subcellular Location |
Cell membrane; Multi-pass membrane protein.
|
| Tissue Specificity |
Abundant in kidney. Lower level expression in lung, skeletal muscle and spleen, lowest expression in testis and not detected in liver brain and heart.
|
| Top Pathways |
Calcium signaling pathway, Neuroactive ligand-receptor interaction
|