Gene Symbol | PTGER1 |
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Entrez Gene | 5731 |
Alt Symbol | EP1 |
Species | Human |
Gene Type | protein-coding |
Description | prostaglandin E receptor 1 (subtype EP1), 42kDa |
Other Description | PGE receptor EP1 subtype|PGE receptor, EP1 subtype|PGE2 receptor EP1 subtype|prostaglandin E receptor 1 (subtype EP1), 42kD|prostaglandin E receptor 1, subtype EP1|prostaglandin E2 receptor EP1 subtype|prostanoid EP1 receptor |
Swissprots | Q86VB5 Q5U5U4 Q86UH3 P34995 Q8NHB2 |
Accessions | BAC05723 EAW84422 P34995 AY275470 AAP32302 BC029768 AAH29768 BC039034 AAH39034 BC051286 AAH51286 L22647 AAC37539 NM_000955 NP_000946 |
Function | Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(q) proteins which activate a phosphatidylinositol-calcium second messenger system. May play a role as an important modulator of renal function. Implicated the smooth muscle contractile response to PGE2 in various tissues. |
Subcellular Location | Cell membrane; Multi-pass membrane protein. |
Tissue Specificity | Abundant in kidney. Lower level expression in lung, skeletal muscle and spleen, lowest expression in testis and not detected in liver brain and heart. |
Top Pathways | Calcium signaling pathway, Neuroactive ligand-receptor interaction |
EP1 CRISPR/Cas9 KO Plasmid (h) - sc-402565 from Santa Cruz Biotechnology
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EP1 HDR Plasmid (h) - sc-402565-HDR from Santa Cruz Biotechnology
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EP1 Double Nickase Plasmid (h) - sc-402565-NIC from Santa Cruz Biotechnology
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EP1 Double Nickase Plasmid (h2) - sc-402565-NIC-2 from Santa Cruz Biotechnology
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EP1 CRISPR Activation Plasmid (h) - sc-402565-ACT from Santa Cruz Biotechnology
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EP1 CRISPR Activation Plasmid (h2) - sc-402565-ACT-2 from Santa Cruz Biotechnology
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EP1 Lentiviral Activation Particles (h) - sc-402565-LAC from Santa Cruz Biotechnology
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EP1 Lentiviral Activation Particles (h2) - sc-402565-LAC-2 from Santa Cruz Biotechnology
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EP1 siRNA (h) - sc-40169 from Santa Cruz Biotechnology
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EP1 shRNA Plasmid (h) - sc-40169-SH from Santa Cruz Biotechnology
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EP1 shRNA (h) Lentiviral Particles - sc-40169-V from Santa Cruz Biotechnology
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PTGER1 RNAi - H00005731-R02 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN17666 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17666 from Sigma-Aldrich
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PTGER1 siRNA (Human) - CRH3875 from Cohesion Biosciences
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shRNA set against Human PTGER1 (NM_000955.2) - SHH385976 from Creative biogene
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shRNA set against Human PTGER1(NM_000955.2) - SHR150490 from Creative biogene
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Human PTGER1 siRNA - orb264377 from Biorbyt
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PTGER1 shRNA Plasmid (Human) - CHH3875 from Cohesion Biosciences
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PTGER1 miRNA 3'UTR clone - MiUTR1H-08416 from Creative biogene
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