GEN1
| Gene Symbol | GEN1 |
|---|---|
| Entrez Gene | 348654 |
| Alt Symbol | Gen |
| Species | Human |
| Gene Type | protein-coding |
| Description | GEN1 Holliday junction 5' flap endonuclease |
| Other Description | Gen endonuclease homolog 1|Gen homolog 1, endonuclease|Holliday junction resolvase|flap endonuclease GEN homolog 1 |
| Swissprots | Q17RS7 Q6ZN37 Q17RS9 |
| Accessions | EAX00865 Q17RS7 AK025489 AK093631 AK098188 BAC05254 AK131387 BAD18538 BC035863 BC038243 BC117204 AAI17205 BC117206 AAI17207 BX490061 CR936783 HQ258680 ADR83431 XM_005262613 XP_005262670 XM_006712005 XP_006712068 XM_011532820 XP_011531122 XM_011532821 XP_011531123 XM_011532822 XP_011531124 NM_001130009 NP_001123481 NM_182625 NP_872431 |
| Function | Endonuclease which resolves Holliday junctions by the introduction of symmetrically related cuts across the junction point, to produce nicked duplex products in which the nicks can be readily ligated. Four-way DNA intermediates, also known as Holliday junctions, are formed during homologous recombination and DNA repair, and their resolution is necessary for proper chromosome segregation. {ECO:0000269|PubMed:19020614}. |
| Subcellular Location | Nucleus {ECO:0000250}. |
GEN1 (G-14) - sc-167969 from Santa Cruz Biotechnology
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GEN1 (S-14) - sc-167970 from Santa Cruz Biotechnology
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Anti-GEN1 antibody - ab102836 from Abcam
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Anti-GEN1 Antibody (aa60-89) - LS-C166438 from LifeSpan Bioscience
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Anti-GEN1 Antibody (aa60-89, APC) - LS-C257672 from LifeSpan Bioscience
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Anti-GEN1 Antibody (aa60-89, AP) - LS-C257671 from LifeSpan Bioscience
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Anti-GEN1 Antibody (aa60-89, Biotin) - LS-C257673 from LifeSpan Bioscience
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Anti-GEN1 Antibody (aa60-89, FITC) - LS-C257674 from LifeSpan Bioscience
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Anti-GEN1 Antibody (aa60-89, Azide-free, HRP) - LS-C257675 from LifeSpan Bioscience
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Anti-GEN1 Antibody (aa60-89, PE) - LS-C257676 from LifeSpan Bioscience
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Anti-GEN1 Antibody (aa67-97) - LS-C321605 from LifeSpan Bioscience
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GEN1 Antibody - NBP2-30783 from Novus Biologicals
![Western Blot: GEN1 Antibody [NBP2-30783] - Analysis in human cell line RH-30.](http://www.bioprodhub.com/system/product_images/ab_products/5/sub_7/29069_GEN1-Antibody-Western-Blot-NBP2-30783-img0004.jpg)
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GEN1 Antibody - NBP2-30836 from Novus Biologicals
![Immunohistochemistry: GEN1 Antibody [NBP2-30836] - Staining of human kidney shows strong cytoplasmic and nuclear positivity in cells in tubules.](http://www.bioprodhub.com/system/product_images/ab_products/5/sub_10/167_GEN1-Antibody-Immunohistochemistry-NBP2-30836-img0001.jpg)
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GEN1 Polyclonal Antibody - bs-13334R from Bioss
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GEN1 Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated - bs-13334R-A350 from Bioss
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GEN1 Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated - bs-13334R-A488 from Bioss
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GEN1 Polyclonal Antibody, ALEXA FLUOR® 555 Conjugated - bs-13334R-A555 from Bioss
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GEN1 Polyclonal Antibody, ALEXA FLUOR® 647 Conjugated - bs-13334R-A647 from Bioss
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GEN1 Polyclonal Antibody, Cy3 Conjugated - bs-13334R-Cy3 from Bioss
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GEN1 Polyclonal Antibody, Cy5 Conjugated - bs-13334R-Cy5 from Bioss
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GEN1 Polyclonal Antibody, Cy5.5 Conjugated - bs-13334R-Cy5.5 from Bioss
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GEN1 Polyclonal Antibody, Cy7 Conjugated - bs-13334R-Cy7 from Bioss
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GEN1 Polyclonal Antibody, FITC Conjugated - bs-13334R-FITC from Bioss
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GEN1 Polyclonal Antibody, Biotin Conjugated - bs-13334R-Biotin from Bioss
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GEN1 Polyclonal Antibody, HRP Conjugated - bs-13334R-HRP from Bioss
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