| Gene Symbol |
GEN1
|
| Entrez Gene |
348654
|
| Alt Symbol |
Gen
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
GEN1 Holliday junction 5' flap endonuclease
|
| Other Description |
Gen endonuclease homolog 1|Gen homolog 1, endonuclease|Holliday junction resolvase|flap endonuclease GEN homolog 1
|
| Swissprots |
Q17RS7 Q6ZN37 Q17RS9
|
| Accessions |
EAX00865 Q17RS7 AK025489 AK093631 AK098188 BAC05254 AK131387 BAD18538 BC035863 BC038243 BC117204 AAI17205 BC117206 AAI17207 BX490061 CR936783 HQ258680 ADR83431 XM_005262613 XP_005262670 XM_006712005 XP_006712068 XM_011532820 XP_011531122 XM_011532821 XP_011531123 XM_011532822 XP_011531124 NM_001130009 NP_001123481 NM_182625 NP_872431
|
| Function |
Endonuclease which resolves Holliday junctions by the introduction of symmetrically related cuts across the junction point, to produce nicked duplex products in which the nicks can be readily ligated. Four-way DNA intermediates, also known as Holliday junctions, are formed during homologous recombination and DNA repair, and their resolution is necessary for proper chromosome segregation. {ECO:0000269|PubMed:19020614}.
|
| Subcellular Location |
Nucleus {ECO:0000250}.
|
![Western Blot: GEN1 Overexpression Lysate (Adult Normal) [NBL1-11042] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for GEN1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/4583_GEN1%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-11042-img0002.jpg)
![Western Blot: GEN1 Overexpression Lysate (Adult Normal) [NBP2-09495] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for GEN1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/24536_GEN1%2520Overexpression%2520Lysate%2520%2528Adult%2520Normal%2529-Western%2520Blot-NBP2-09495-img0001.jpg)