| Gene Symbol |
AKAP10
|
| Entrez Gene |
11216
|
| Alt Symbol |
AKAP-10, D-AKAP-2, D-AKAP2, PRKA10
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
A kinase (PRKA) anchor protein 10
|
| Other Description |
A-kinase anchor protein 10, mitochondrial|dual specificity A kinase-anchoring protein 2|mitochondrial A kinase PPKA anchor protein 10|protein kinase A anchoring protein 10
|
| Swissprots |
Q96AJ7 B2R650 O43572
|
| Accessions |
EAW50913 O43572 AF037439 AAB92260 AK295180 BAH12002 AK308297 AK312438 BAG35347 BC017055 AAH17055 BC111518 BP229845 DQ270159 ABB76684 DQ891477 ABM82403 DQ894666 ABM85592 U00957 XM_006721431 XP_006721494 XM_006721432 XP_006721495 XR_243536 XR_933969 XR_933970 NM_007202 NP_009133
|
| Function |
Differentially targeted protein that binds to type I and II regulatory subunits of protein kinase A and anchors them to the mitochondria or the plasma membrane. Although the physiological relevance between PKA and AKAPS with mitochondria is not fully understood, one idea is that BAD, a proapoptotic member, is phosphorylated and inactivated by mitochondria-anchored PKA. It cannot be excluded too that it may facilitate PKA as well as G protein signal transduction, by acting as an adapter for assembling multiprotein complexes. With its RGS domain, it could lead to the interaction to G-alpha proteins, providing a link between the signaling machinery and the downstream kinase (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Mitochondrion {ECO:0000269|PubMed:11248059}. Membrane {ECO:0000269|PubMed:11248059}. Cytoplasm {ECO:0000269|PubMed:11248059}. Note=Predominantly mitochondrial but also membrane associated and cytoplasmic.
|