Gene Symbol | AKAP10 |
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Entrez Gene | 11216 |
Alt Symbol | AKAP-10, D-AKAP-2, D-AKAP2, PRKA10 |
Species | Human |
Gene Type | protein-coding |
Description | A kinase (PRKA) anchor protein 10 |
Other Description | A-kinase anchor protein 10, mitochondrial|dual specificity A kinase-anchoring protein 2|mitochondrial A kinase PPKA anchor protein 10|protein kinase A anchoring protein 10 |
Swissprots | Q96AJ7 B2R650 O43572 |
Accessions | EAW50913 O43572 AF037439 AAB92260 AK295180 BAH12002 AK308297 AK312438 BAG35347 BC017055 AAH17055 BC111518 BP229845 DQ270159 ABB76684 DQ891477 ABM82403 DQ894666 ABM85592 U00957 XM_006721431 XP_006721494 XM_006721432 XP_006721495 XR_243536 XR_933969 XR_933970 NM_007202 NP_009133 |
Function | Differentially targeted protein that binds to type I and II regulatory subunits of protein kinase A and anchors them to the mitochondria or the plasma membrane. Although the physiological relevance between PKA and AKAPS with mitochondria is not fully understood, one idea is that BAD, a proapoptotic member, is phosphorylated and inactivated by mitochondria-anchored PKA. It cannot be excluded too that it may facilitate PKA as well as G protein signal transduction, by acting as an adapter for assembling multiprotein complexes. With its RGS domain, it could lead to the interaction to G-alpha proteins, providing a link between the signaling machinery and the downstream kinase (By similarity). {ECO:0000250}. |
Subcellular Location | Mitochondrion {ECO:0000269|PubMed:11248059}. Membrane {ECO:0000269|PubMed:11248059}. Cytoplasm {ECO:0000269|PubMed:11248059}. Note=Predominantly mitochondrial but also membrane associated and cytoplasmic. |
AKAP 10 CRISPR/Cas9 KO Plasmid (h) - sc-409815 from Santa Cruz Biotechnology
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AKAP 10 HDR Plasmid (h) - sc-409815-HDR from Santa Cruz Biotechnology
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AKAP 10 Double Nickase Plasmid (h) - sc-409815-NIC from Santa Cruz Biotechnology
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AKAP 10 Double Nickase Plasmid (h2) - sc-409815-NIC-2 from Santa Cruz Biotechnology
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AKAP 10 CRISPR Activation Plasmid (h) - sc-409815-ACT from Santa Cruz Biotechnology
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AKAP 10 CRISPR Activation Plasmid (h2) - sc-409815-ACT-2 from Santa Cruz Biotechnology
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AKAP 10 Lentiviral Activation Particles (h) - sc-409815-LAC from Santa Cruz Biotechnology
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AKAP 10 Lentiviral Activation Particles (h2) - sc-409815-LAC-2 from Santa Cruz Biotechnology
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AKAP 10 siRNA (h) - sc-93998 from Santa Cruz Biotechnology
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AKAP 10 shRNA Plasmid (h) - sc-93998-SH from Santa Cruz Biotechnology
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AKAP 10 shRNA (h) Lentiviral Particles - sc-93998-V from Santa Cruz Biotechnology
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AKAP10 RNAi - H00011216-R01V from Novus Biologicals
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AKAP10 RNAi - H00011216-R02 from Novus Biologicals
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MISSION® esiRNA - EHU022291 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN3002 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3002 from Sigma-Aldrich
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AKAP10 siRNA (Human) - CRH7685 from Cohesion Biosciences
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AKAP10 - MBS8204960 from MyBioSource
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shRNA set against Human Akap10 (NM_007202.3) - SHH234174 from Creative biogene
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AKAP10 shRNA Plasmid (Human) - CHH7685 from Cohesion Biosciences
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AKAP10 miRNA 3'UTR clone - MiUTR3H-07016 from Creative biogene
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