Gene Symbol | AKAP10 |
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Entrez Gene | 11216 |
Alt Symbol | AKAP-10, D-AKAP-2, D-AKAP2, PRKA10 |
Species | Human |
Gene Type | protein-coding |
Description | A kinase (PRKA) anchor protein 10 |
Other Description | A-kinase anchor protein 10, mitochondrial|dual specificity A kinase-anchoring protein 2|mitochondrial A kinase PPKA anchor protein 10|protein kinase A anchoring protein 10 |
Swissprots | Q96AJ7 B2R650 O43572 |
Accessions | EAW50913 O43572 AF037439 AAB92260 AK295180 BAH12002 AK308297 AK312438 BAG35347 BC017055 AAH17055 BC111518 BP229845 DQ270159 ABB76684 DQ891477 ABM82403 DQ894666 ABM85592 U00957 XM_006721431 XP_006721494 XM_006721432 XP_006721495 XR_243536 XR_933969 XR_933970 NM_007202 NP_009133 |
Function | Differentially targeted protein that binds to type I and II regulatory subunits of protein kinase A and anchors them to the mitochondria or the plasma membrane. Although the physiological relevance between PKA and AKAPS with mitochondria is not fully understood, one idea is that BAD, a proapoptotic member, is phosphorylated and inactivated by mitochondria-anchored PKA. It cannot be excluded too that it may facilitate PKA as well as G protein signal transduction, by acting as an adapter for assembling multiprotein complexes. With its RGS domain, it could lead to the interaction to G-alpha proteins, providing a link between the signaling machinery and the downstream kinase (By similarity). {ECO:0000250}. |
Subcellular Location | Mitochondrion {ECO:0000269|PubMed:11248059}. Membrane {ECO:0000269|PubMed:11248059}. Cytoplasm {ECO:0000269|PubMed:11248059}. Note=Predominantly mitochondrial but also membrane associated and cytoplasmic. |
Human AKAP10 full length protein - ab132242 from Abcam
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Human AKAP10 peptide - ab45572 from Abcam
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Human AKAP10 protein fragment - ab161354 from Abcam
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AKAP10 Antibody Blocking Peptide - LS-E25706 from LifeSpan Bioscience
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AKAP10 Antibody Blocking Peptide - LS-E13004 from LifeSpan Bioscience
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AKAP10 Antibody Blocking Peptide - LS-E26761 from LifeSpan Bioscience
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Recombinant Human AKAP10 Protein - H00011216-P01 from Novus Biologicals
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Recombinant Human AKAP10 Protein - H00011216-Q01 from Novus Biologicals
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AKAP10 blocking peptide - GTX88680-PEP from GeneTex
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AKAP10 blocking peptide - GTX89747-PEP from GeneTex
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Goat anti AKAP10 antibody Immunizing peptide - orb55084 from Biorbyt
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AKAP10 Blocking Peptide - 33R-2735 from Fitzgerald
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AKAP10 Peptide - AC21-0536-P from Abcore
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AKAP10 Peptide - AC21-1596-P from Abcore
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AKAP10 - H00011216-P01-10 from Acris Antibodies
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AKAP10 - H00011216-P01-25 from Acris Antibodies
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AKAP10 - H00011216-Q01-10 from Acris Antibodies
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AKAP10 - H00011216-Q01-25 from Acris Antibodies
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AKAP10 Peptide - 45-228P from ProSci
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D-AKAP2 Peptide - 45-458P from ProSci
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AKAP10 fusion protein - ag3020 from Proteintech Group
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Recombinant Human AKAP10, His-tagged - AKAP10-3022H from Creative Biomart
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AKAP10 Blocking Peptide - CBP3390 from Cohesion Biosciences
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AKAP 10 (R27) Peptide - BS1877P from Bioworld Technology
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Recombinant Human A-kinase anchor protein 10, mitochondrial(AKAP10) - CSB-YP001519HU CSB-EP001519HU CSB-BP001519HU CSB-MP001519HU from Cusabio
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